THE IMPORTANCE OF THE HYDROPHOBIC INTERACTION IN THE MUTAGENICITY OF ORGANIC-COMPOUNDS

被引：61

作者：

DEBNATH, AK

SHUSTERMAN, AJ

DECOMPADRE, RLL

HANSCH, C

机构：

[1] REED COLL, DEPT CHEM, PORTLAND, OR 97202 USA

[2] UNIV ARKANSAS MED SCI HOSP, DEPT BIOPHARMACEUT SCI, LITTLE ROCK, AR 72205 USA

来源：

MUTATION RESEARCH | 1994年 / 305卷 / 01期

关键词：

HYDROPHOBIC INTERACTION; ORGANIC COMPOUNDS; QSAR; NITRO COMPOUNDS;

D O I：

10.1016/0027-5107(94)90126-0

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The derivation of new QSAR and the review of published QSAR for the mutagenicity of a variety of chemicals acting on a variety of bacterial systems uncovers two classes of equations. 12 examples include a term for hydrophobicity and of these 12, 11 require activation either by S9 or cytosolic enzymes for the reduction of nitro compounds. There are 4 examples of direct-acting mutagens which do not require activation. Of these 4, 3 do not contain a term for hydrophobicity. The odd example is that of the sulfonate esters which do not require activation, but contain a term in log P. The hydrophobicity factor is not correlated with the type of bacteria used for the test.

引用

页码：63 / 72

页数：10

共 30 条

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