IDENTIFICATION OF ETHANOLAMINE IN RAT AND GERBIL BRAIN-TISSUE EXTRACTS BY NMR-SPECTROSCOPY

被引：21

作者：

SMART, SC

FOX, GB

ALLEN, KL

SWANSON, AG

NEWMAN, MJ

SWAYNE, GTG

CLARK, JB

SALES, KD

WILLIAMS, SCR

机构：

[1] PFIZER LTD,CENT RES,SANDWICH CT13 9NJ,KENT,ENGLAND

[2] INST NEUROL,DEPT NEUROCHEM,LONDON WC1N 3BG,ENGLAND

来源：

NMR IN BIOMEDICINE | 1994年 / 7卷 / 08期

关键词：

D O I：

10.1002/nbm.1940070806

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Some NMR resonances which have previously been observed but not identified in mammalian brain tissue extracts have been shown to arise from ethanolamine. This conclusion is drawn from a systematic study of the perchloric acid extracts of rodent brain tissue in which several NMR experiments were used to assign the peaks unambiguously. The extraction procedure used in this work gave samples with highly reproducible spectra, and ethanolamine was observed in all our extract samples. A localized increase in the concentration of ethanolamine was seen in the spectra of extracts produced from a cerebral infarct induced by occlusion of the middle cerebral artery in the rat.

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页码：356 / 365

页数：10

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