QUANTITATIVE-DETERMINATION OF PODOPHYLLOTOXIN AND RELATED-COMPOUNDS IN PODOPHYLLUM SPECIES BY REVERSE-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：14

作者：

BASTOS, JK

KOPYCKI, WJ

BURANDT, CL

NANAYAKKARA, NPD

MCCHESNEY, JD

机构：

[1] UNIV MISSISSIPPI,SCH PHARM,PHARMACEUT SCI RES INST,UNIVERSITY,MS 38677

[2] UNIV MISSISSIPPI,SCH PHARM,DEPT PHARMACOGNOSY,UNIVERSITY,MS 38677

来源：

PHYTOCHEMICAL ANALYSIS | 1995年 / 6卷 / 02期

关键词：

PODOPHYLLOTOXIN DERIVATIVES; QUANTITATIVE REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PODOPHYLLUM EMODII WALLICH EX ROYLE; PODOPHYLLUM PELTATUM L;

D O I：

10.1002/pca.2800060207

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A rapid sensitive and reliable reverse phase high performance liquid chromatography method was developed using a Taxsil(R) column and gradient elution for the routine determination of podophyllotoxin and six related compounds, epipodophyllotoxin, alpha-peltatin, beta-peltatin, 4'-demethylpodophyllotoxin, podophyllotoxin-4-O-glycoside, and 1,2,3,4-dehydradesoxypodophyllotoxin in Podophyllum extracts. The elaborated method gave well resolved peaks for these compounds with good detection response and linearity in the range 25-450 ng.

引用

页码：101 / 105

页数：5

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