AUTONOMIC MEDIATION OF SHORT-TERM CARDIOVASCULAR OSCILLATIONS AFTER ACUTE HEMORRHAGE IN CONSCIOUS RATS

被引:24
作者
GONZALEZ, JG [1 ]
VALERIANO, JJC [1 ]
RODRIGUEZ, MF [1 ]
机构
[1] UNIV LA LAGUNA,FAC MED,DEPT PHARMACOL,LA LAGUNA,SPAIN
来源
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM | 1995年 / 55卷 / 1-2期
关键词
ACUTE HEMORRHAGE; SPECTRAL ANALYSIS; BLOOD PRESSURE OSCILLATION; R-R INTERVAL OSCILLATION; AUTONOMIC CONTROL; RENIN-ANGIOTENSIN SYSTEM;
D O I
10.1016/0165-1838(95)00038-Y
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The role of the autonomic and the renin-angiotensin (R-A) activities in short-term cardiovascular control during the bradycardic phase following severe hemorrhage was investigated in conscious rats. Spectral analysis of beat-to-beat fluctuations of the R-R interval (RRI), systolic (SEP) and diastolic (DBP) blood pressure in the 0.01-5-Hz range was carried out under control conditions and following a bleeding of 30% of total blood volume, with and without i.v injection of atropine (2 mg/kg), prazosin (2 mg/kg), propranolol (5 mg/kg) or captopril (7 mg/kg). The bradycardic stage was characterized by: (i) an increase of the three oscillatory components exhibited by RRI variability which appears driven by vagal activity and buffered by beta-adrenergic activity, while the increase of the slower LF (0.01-0.2 Hz) oscillations seems driven by the slow alpha-adrenergic control; (ii) a decrease of SEP and DBP oscillations and absence of SBP-RRI correlation in the MF band (0.2-0.6 Hz) possibly related to a decrease in the sympathetic drive of SBP-MF and DBP-MF oscillations and in RRI baroreflex control; (iii) an increase in LF oscillations of SEP and even more of DBP that seems driven by the slow alpha- and beta-adrenergic control and buffered by the R-A control, responses possibly related to an increase of LF oscillations of peripheral resistance; (iv) the persistence of high SBP-RRI correlation in the LF band and in the respiratory band (1-3 Hz); the former seem to reflect the existence of a slow baroreflex control mediated by beta-adrenergic activity, the latter appears to be caused by feedforward mechanical effects of RRI changes on SEP.
引用
收藏
页码:123 / 130
页数:8
相关论文
共 33 条
[1]   HEMODYNAMIC REGULATION - INVESTIGATION BY SPECTRAL-ANALYSIS [J].
AKSELROD, S ;
GORDON, D ;
MADWED, JB ;
SNIDMAN, NC ;
SHANNON, DC ;
COHEN, RJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 249 (04) :H867-H875
[2]   HEMODYNAMIC REGULATION IN SHR - INVESTIGATION BY SPECTRAL-ANALYSIS [J].
AKSELROD, S ;
ELIASH, S ;
OZ, O ;
COHEN, S .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 253 (01) :H176-H183
[3]  
AKSELROD S, 1993, BLOOD PRESSURE HEART, P192
[4]   SPECTRAL AND CROSS-SPECTRAL ANALYSIS OF HEART-RATE AND ARTERIAL BLOOD-PRESSURE VARIABILITY SIGNALS [J].
BASELLI, G ;
CERUTTI, S ;
CIVARDI, S ;
LIBERATI, D ;
LOMBARDI, F ;
MALLIANI, A ;
PAGANI, M .
COMPUTERS AND BIOMEDICAL RESEARCH, 1986, 19 (06) :520-534
[5]  
BENDAT JS, 1971, RANDOM DATA ANAL MEA
[6]  
BERGER DB, 1989, AM J PHYSIOL, V256, pH141
[7]   ROLE OF VASOPRESSIN IN ACUTELY ALTERED BAROREFLEX SENSITIVITY DURING HEMORRHAGE IN RATS [J].
BRIZZEE, BL ;
RUSS, RD ;
WALKER, BR .
AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 261 (03) :R677-R685
[8]   CIRCULATORY CONTROL VIA VAGAL AFFERENTS .1. ADJUSTMENT OF HEART-RATE TO VARIATIONS OF BLOOD-VOLUME IN RAT [J].
CASTENFORS, J ;
SJOSTRAND, T .
ACTA PHYSIOLOGICA SCANDINAVICA, 1972, 84 (03) :347-+
[9]   BAROREFLEX MODULATION OF BLOOD-PRESSURE AND HEART-RATE VARIABILITIES IN RATS - ASSESSMENT BY SPECTRAL-ANALYSIS [J].
CERUTTI, C ;
BARRES, C ;
PAULTRE, C .
AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (05) :H1993-H2000
[10]   AUTONOMIC NERVOUS-SYSTEM AND CARDIOVASCULAR VARIABILITY IN RATS - A SPECTRAL-ANALYSIS APPROACH [J].
CERUTTI, C ;
GUSTIN, MP ;
PAULTRE, CZ ;
LO, M ;
JULIEN, C ;
VINCENT, M ;
SASSARD, J .
AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 261 (04) :H1292-H1299