ACROLEIN MUTAGENICITY IN THE V79 ASSAY

被引：47

作者：

SMITH, RA

COHEN, SM

LAWSON, TA

机构：

[1] UNIV NEBRASKA, MED CTR, DEPT PATHOL & MICROBIOL, OMAHA, NE 68105 USA

[2] UNIV NEBRASKA, MED CTR, EPPLEY INST RES CANC & ALLIED DIS, OMAHA, NE 68105 USA

来源：

CARCINOGENESIS | 1990年 / 11卷 / 03期

关键词：

D O I：

10.1093/carcin/11.3.497

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The mutagenicity of acrolein, allyl alcohol, glycidol and propionaldehyde was measured in V79 cells as resistance to 6-thioguanine. Acrolein was tested with and without fetal bovine serum (FBS) (10%; v/v) during the 2 h incubation period. The concentration of FBS did not affect acrolein toxicity but its mutagenicity declined as the concentration of FBS in the medium rose. Allyl alcohol (AA) was as mutagenic as acrolein (ACR). Glycidol was less mutagenic than AA and ACR. Propionaldehyde was not mutagenic at 1 μM; it was toxic at 2 μM. The data suggest that the mutagenicity of these compounds is mediated by their bifunctional nature whereas their cytotoxicity is mediated by the aldehyde function. © 1990 Oxford University Press.

引用

页码：497 / 498

页数：2

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