INVIVO AND INVITRO DEGRADATION OF POLY(3-HYDROXYBUTYRATE) IN RAT

被引：60

作者：

SAITO, T

TOMITA, K

JUNI, K

OOBA, K

机构：

[1] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT HLTH CHEM,SAKYO KU,KYOTO 606,JAPAN

[2] JOSAI UNIV,FAC PHARMACEUT SCI,DEPT PHARMACEUT,SAKADO,SAITAMA 35002,JAPAN

[3] LION CORP,BIOL SCI LAB,ODAWARA,KANAGAWA 256,JAPAN

来源：

BIOMATERIALS | 1991年 / 12卷 / 03期

关键词：

POLYHYDROXYBUTYRATE; RATS; INFLAMMATION;

D O I：

10.1016/0142-9612(91)90039-D

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The inflammatory activity and biodegradation of poly(3-hydroxybutyrate) were examined. Poly (3-hydroxybutyrate) sheet did not cause any inflammation in the chorioallantoic membrane of the developing egg. The i.v. injection of C-14-labelled poly(3-hydroxybutyrate) granules showed that 86, 2.5 and 2.4% of the total radioactivity administered were distributed in the liver, spleen and lung, respectively, and the radioactivity decreased slowly but steadily in most tissues examined during 2 month. Crude extracts of rat tissues showed that the activity degraded the poly(3-hydroxybutyrate) granules in vitro.

引用

页码：309 / 312

页数：4

共 16 条

[1] BISSERY MC, 1984, MICROSPHERES DRUG TH, P217
[2] INVITRO AND INVIVO STUDIES ON BIODEGRADABLE POLYESTER MICROPARTICLES CONTAINING SULFAMETHIZOLE
BROPHY, MR
DEASY, PB
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1986, 29 (2-3) : 223 - 231
[3] SOME ASPECTS OF ENDOGENOUS METABOLISM OF BACTERIA
DAWES, EA
RIBBONS, DW
[J]. BACTERIOLOGICAL REVIEWS, 1964, 28 (02) : 126 - &
[4] DUNLOP WF, 1973, J BACTERIOL, V114, P1272
[5] MORPHOLOGY OF POLY-BETA-HYDROXYBUTYRATE GRANULES
ELLAR, D
LUNDGREN, DG
OKAMURA, K
MARCHESSAULT, RH
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1968, 35 (03) : 489 - +
[6] ENZYMATIC-SYNTHESIS OF POLY-BETA-HYDROXYBUTYRATE IN ZOOGLOEA-RAMIGERA
FUKUI, T
YOSHIMOTO, A
MATSUMOTO, M
HOSOKAWA, S
SAITO, T
NISHIKAWA, H
TOMITA, K
[J]. ARCHIVES OF MICROBIOLOGY, 1976, 110 (2-3) : 149 - 156
[7] HIPPE H, 1967, ARCH MIKROBIOL, V56, P278
[8] APPLICATIONS OF PHB - A MICROBIALLY PRODUCED BIODEGRADABLE THERMOPLASTIC
HOLMES, PA
[J]. PHYSICS IN TECHNOLOGY, 1985, 16 (01): : 32 - 36
[9] JUNI K, 1986, Journal of Controlled Release, V4, P25
[10] CLEARANCE OF CE-14-LABELED MICROSPHERES FROM BLOOD AND DISTRIBUTION IN SPECIFIC ORGANS FOLLOWING INTRAVENOUS AND INTRA-ARTERIAL ADMINISTRATION IN BEAGLE DOGS
KANKE, M
SIMMONS, GH
WEISS, DL
BIVINS, BA
DELUCA, PP
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1980, 69 (07) : 755 - 762

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