THE TREATMENT OF DETRUSOR INSTABILITY IN POSTMENOPAUSAL WOMEN WITH OXYBUTYNIN CHLORIDE - A DOUBLE-BLIND PLACEBO CONTROLLED-STUDY

被引：95

作者：

TAPP, AJS

CARDOZO, LD

VERSI, E

COOPER, D

机构：

[1] LONDON HOSP,DEPT OBSTET & GYNAECOL,LONDON E1 1BB,ENGLAND

[2] UNIV LONDON KINGS COLL HOSP,SCH MED,COMP UNIT,LONDON SE5 8RX,ENGLAND

[3] UNIV LONDON KINGS COLL HOSP,DEPT OBSTET & GYNAECOL,LONDON SE5 8RX,ENGLAND

来源：

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 1990年 / 97卷 / 06期

关键词：

D O I：

10.1111/j.1471-0528.1990.tb02523.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Summary. Idiopathic detrusor instability is a common cause of incontinence in the elderly for which anticholinergic agents arc regularly prescribed. Oxybutynin chloride combines anticholinergic action with direct muscle relaxant properties. We performed a double blind placebo controlled fixed dose cross over study of oxybutynin chloride in postmenopausal women suffering from detrusor instability. We found oxybutynin chloride significantly more effective than placebo at reducing the symptoms of urgency and urge incontinence and more effective at reducing the height of the highest unstable detrusor contraction. This was at the expense of an increased residual urine and considerable side effects. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：521 / 526

页数：6

共 6 条

[1]

ABRAMS P, 1984, SCAND J UROL NEPHROL, V87, P1

[2]

BATES C P, 1970, British Journal of Urology, V42, P714, DOI 10.1111/j.1464-410X.1970.tb06796.x

[3]

CARDOZO LD, 1987, UROGENITAL DEFICIENC, P10

[4] OXYBUTYNIN - NEW DRUG WITH ANALGESIC AND ANTICHOLINERGIC PROPERTIES [J].