RECURRENT SPLEEN ENLARGEMENT DURING CYCLIC GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR THERAPY FOR MYELODYSPLASTIC SYNDROME

被引：16

作者：

DELMER, A ^{[1
]}

KARMOCHKINE, M ^{[1
]}

CADIOU, M ^{[1
]}

GERHARTZ, H ^{[1
]}

ZITTOUN, R ^{[1
]}

机构：

[1] UNIV MUNICH,KLINIKUM GROSSHADERN,MED KLIN 3,W-8000 MUNICH 70,GERMANY

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1990年 / 34卷 / 01期

关键词：

side effect; splenomegaly;

D O I：

10.1002/ajh.2830340117

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 65‐year‐old woman with refractory anemia with excess of blasts received sequential courses of granulocyte‐macrophage colony‐stimulating factor therapy (GM‐CSF) and low‐dose cytosine arabinoside. Each course of GM‐CSF induced a rapid and tremendous increase in leukocyte count as well as in spleen size, 111indium chloride scanning suggested a myeloid metaplasia of the spleen. This observation suggests that in some patients the granulopoietic response to the myeloid growth factor stimulation may be predominant in the spleen. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：73 / 74

页数：2

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