FURTHER-STUDIES ON THE ADJUVANT EFFECT OF SILICA ON IGE ANTIBODY-PRODUCTION IN MICE

被引：13

作者：

MANCINO, D ^{[1
]}

BEVILACQUA, N ^{[1
]}

机构：

[1] UNIV NAPLES, SCH MED & SURG 1, INST GEN PATHOL, I-80138 NAPLES, ITALY

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1979年 / 59卷 / 04期

关键词：

D O I：

10.1159/000232290

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The effects of amorphous silica (aerosil) and of Al(OH)3 on anti-DNP [dinitrophenyl] Ig[immunoglobulin]E antibody production were studied in Swiss mice preimmunized with Ascaris protein [ASC] and then challenged 7 days later with DNP-ASC. Aerosil exerted an adjuvant effect especially when it was injected together with the DNP-ASC conjugate. Al(OH)3 had a weaker adjuvant effect than that produced by aerosil and only when it was injected with the DNP-ASC conjugate. Al(OH)3 given with Ascaris extract 7 days before complete antigen had an inhibitory effect on the anti-DNP IgE antibody production.

引用

页码：427 / 431

页数：5

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