MAUVE FACTOR OF SCHIZOPHRENIA AND PORPHYRIA, 5-HYDROXYHEMOPYRROLE LACTAM, HAS LOW PHARMACOLOGICAL POTENCY ON GUINEA-PIG ILEUM

被引：5

作者：

GORCHEIN, A

ROGERS, AT

机构：

[1] Department of Clinical Pharmacology and Therapeutics, St Mary's Hospital Medical School, London, W2, Praed Street

来源：

EXPERIENTIA | 1979年 / 35卷 / 08期

关键词：

D O I：

10.1007/BF01949952

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

5-Hydroxyhaemopyrrole lactam, the 'mauve factor' reported in the urine of schizophrenics and porphyrics was found to inhibit electrically-stimulated contractions of guinea-pig ileum only at high concentrations (ID50=8.5 mM). This low potency makes it unlikely that the compound can account for neurotoxic effects in human porphyria. © 1979 Birkhäuser Verlag.

引用

页码：1078 / 1079

页数：2

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