GENERATION OF PLASMA KININ BY 3 TYPES OF PROTEASE ISOLATED FROM PORPHYROMONAS-GINGIVALIS-381

被引：19

作者：

HINODE, D ^{[1
]}

NAGATA, A ^{[1
]}

ICHIMIYA, S ^{[1
]}

HAYASHI, H ^{[1
]}

MORIOKA, M ^{[1
]}

NAKAMURA, R ^{[1
]}

机构：

[1] UNIV TOKUSHIMA,SCH DENT,DEPT PREVENT MED,18-15 KURAMOTOCHO 3-CHOME,TOKUSHIMA 770,JAPAN

来源：

ARCHIVES OF ORAL BIOLOGY | 1992年 / 37卷 / 10期

关键词：

KININ GENERATION; PROTEASE; PORPHYROMONAS-GINGIVALIS; PERIODONTAL DISEASE;

D O I：

10.1016/0003-9969(92)90120-W

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Three types of protease (A, B and C) isolated from the culture supernatant of Porphyromonas gingivalis 381 had peculiar activities on kinin generation from high molecular-weight kininogen in vitro. Protease C released bradykinin from the kininogen in a reaction mixture containing 2 mM dithiothreitol, but A and B did not. However, the activity of degrading bradykinin was much stronger in protease A and B than in C. These findings suggest that only protease C shows plasma kallikrein activity.

引用

页码：859 / 861

页数：3

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