PZ-51 (EBSELEN) INVIVO PROTECTION AGAINST ADRIAMYCIN-INDUCED MOUSE CARDIAC AND HEPATIC LIPID-PEROXIDATION AND TOXICITY

被引：37

作者：

PRITSOS, CR ^{[1
]}

SOKOLOFF, M ^{[1
]}

GUSTAFSON, DL ^{[1
]}

机构：

[1] UNIV NEVADA,PHYSIOL PROGRAM,RENO,NV 89557

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 44卷 / 04期

关键词：

D O I：

10.1016/0006-2952(92)90427-K

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Adriamycin(R) (Adr)-induced cardiotoxicity occurs most likely via an oxidative mechanism of action. Moderation of this activity may result in an improved therapeutic index for this compound. PZ-51, 2-phenyl-1,2-benzoisoselenazol-3(2H)-one, is a selenoorganic compound with thiol-dependent, peroxidase-like activity. We tested this compound alone and in combination with N-acetylcysteine (NAC) for its effect on Adr-induced in vivo toxicity in Balb/c mice. These studies demonstrated that PZ-51 protects against Adr-induced lipid peroxidation in heart and liver tissue and Adr-induced toxicity in general, as measured by total serum creatine kinase activity and body weight.

引用

页码：839 / 841

页数：3

共 21 条

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