COMPARISON OF TL-201 AND TC-99M METHOXYISOBUTYL ISONITRILE

被引：15

作者：

WACKERS, FJT

机构：

[1] Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1992年 / 70卷 / 14期

关键词：

D O I：

10.1016/0002-9149(92)90036-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thallium-201 (Tl-201) is a well-established radionuclide used in myocardial perfusion imaging for assessing the presence and prognostic significance of coronary artery disease. Recently, technetium-99m hexakis-2-methoxyisobutyl isonitrile (Tc-99m-sestamibi) has become available for the same diagnostic and prognostic procedures. This discussion compares the imaging characteristics and clinical applications of Tl-201 with those of Tc-99m-sestamibi. There is a strong diagnostic concordance between the 2 agents in symptomatic patients. Various comparative clinical trials have shown in numerous patients that both agents have a similar diagnostic yield in both planar and single-photon emission computed tomography (SPECT) imaging. Because of better image quality of the Tc-99m agent, ther is a trend toward better specificity and normalcy rate, in comparison to Tl-201. However, when using reinjection imaging protocols, Tl-201 retains a unique place as in imaging agent to identify viable myocardium.

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页码：E30 / E34

页数：5

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