ANESTHETIC PHENCYCLIDINE, BLOCKER OF THE ATP-SENSITIVE POTASSIUM CHANNELS

被引：8

作者：

KOKOZ, YM

ALEKSEEV, AE

POVZUN, AA

KORYSTOVA, AF

PERESSAAD, H

机构：

[1] Laboratory of Functional Biochemistry, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino

来源：

FEBS LETTERS | 1994年 / 337卷 / 03期

关键词：

ATP-SENSITIVE K-CHANNEL; PHENCYCLIDINE; CALCIUM CURRENT; CARDIOMYOCYTE; PATCH CLAMP;

D O I：

10.1016/0014-5793(94)80208-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The double sucrose gap and patch-clamp studies revealed that phencyclidine blocked the ATP-sensitive K+ channel in isolated cardiac cells (half-maximal inhibition at approximate to 20 mu M; Hill coefficient approximate to 1). 10 mu M phencyclidine increased the inward Ca2+ current and blocked the outward K+ current in the frog auricle trabeculae. The phencyclidine effects on the frog auricle trabeculae and the isolated cardiac cells proved to be quite reversible.

引用

页码：277 / 280

页数：4

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