ALPHA-INTERFERON IN MYELOFIBROSIS - A CASE-REPORT

被引：19

作者：

DALLA, KP ^{[1
]}

ZEIGLER, ZR ^{[1
]}

SHADDUCK, RK ^{[1
]}

机构：

[1] WESTERN PENN HOSP,WESTERN PENN CTR INST,PITTSBURGH,PA 15224

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1994年 / 86卷 / 03期

关键词：

INTERFERON; MYELOID METAPLASIA; MARROW FIBROSIS;

D O I：

10.1111/j.1365-2141.1994.tb04802.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A patient with advanced myeloid metaplasia was treated with alpha-interferon (29 months) with a remarkable response. He had anaemia, thrombocytopenia and hepatosplenomegaly with infarction. The initial bone marrow showed replacement with fibrosis with no evident haemopoietic cells. Post-therapy, the patient became asymptomatic, transfusion independent and had normal blood counts. The repeat bone marrow was 30% cellular with 1 + reticulin and no fibrosis. Treatment was well tolerated without appreciable side-effects. These results indicate that prolonged therapy with alpha-interferon can improve haemopoiesis and reverse marrow fibrosis.

引用

页码：654 / 656

页数：3

共 9 条

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