REACTIVITY OF ORGANOPHOSPHORUS COMPOUNDS .24. ACIDIC HYDROLYSIS OF DIALKYL METHYLPHOSPHONATES

被引：13

作者：

CADOGAN, JIG

EASTLICK, D

HAMPSON, F

MACKIE, RK

机构：

[1] Department of Chemistry, University of St. Andrews, St. Andrews

来源：

JOURNAL OF THE CHEMICAL SOCIETY B-PHYSICAL ORGANIC | 1969年 / 02期

关键词：

D O I：

10.1039/j29690000144

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rates of acidic hydrolysis of dialkyl methylphosphonates [(RO) 2P(O)Me and (RO)(EtO)P(O)Me, where R is primary, secondary (mainly), and tertiary] at 100° in 50% aqueous dioxan, containing benzenesulphonic acid (1N), have been measured and the relative rates of hydrolysis are compared with the previously reported relative rates of ageing of phosphonylated cholinesterases.

引用

页码：144 / &

共 13 条

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BENSCHOP, HP
KEIJER, JH
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[2] CADOGAN JIG, 1969, J CHEM SOC B, P138
[3] CADOGAN MIG, 1967, J CHEM SOC C, P1356
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MARSH, DJ
READ, G
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[5] MECHANISMS OF NUCLEOPHILIC SUBSTITUTION IN PHOSPHATE ESTERS
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RAMSAY, OB
[J]. CHEMICAL REVIEWS, 1964, 64 (04) : 317 - &
[6] DEALKYLATION AS A MECHANISM FOR AGING OF CHOLINESTERASE AFTER POISONING WITH PINACOLYL METHYLPHOSPHONOFLUORIDATE
FLEISHER, JH
HARRIS, LW
[J]. BIOCHEMICAL PHARMACOLOGY, 1965, 14 (05) : 641 - +
[7] FROST AA, 1961, KINETICS MECHANISM, P171
[8] DEALKYLATION AND HYDROLYSIS OF ALKYL PHOSPHITES, PHOSPHATES, AND PHOSPHONATES
GERRARD, W
GREEN, WJ
NUTKINS, RA
[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1952, (OCT): : 4076 - 4078
[9] HUDSON RF, 1956, J CHEM SOC, P2465
[10] KEAY L, 1963, J ORG CHEM, V28, P1426

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