THE EFFECTS OF HANDLING ON ANTIBODY-PRODUCTION, MITOGEN RESPONSES, SPLEEN-CELL NUMBER, AND LYMPHOCYTE SUBPOPULATIONS

被引：32

作者：

MOYNIHAN, J ^{[1
]}

BRENNER, G ^{[1
]}

KOOTA, D ^{[1
]}

BRENEMAN, S ^{[1
]}

COHEN, N ^{[1
]}

ADER, R ^{[1
]}

机构：

[1] UNIV ROCHESTER,MED CTR,DEPT MICROBIOL & IMMUNOL,ROCHESTER,NY 14642

来源：

LIFE SCIENCES | 1990年 / 46卷 / 26期

关键词：

D O I：

10.1016/0024-3205(90)90509-P

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of a simple psychosocial manipulation, handling, on immune function in BALB/c.ByJ mice were studied. Handling for two minutes/day prior to immunization was shown to be associated with a decreased primary IgG antibody response to the protein antigen keyhole limpet hemocyanin. Handling was also associated with decreased T cell proliferative responses to Concanavalin. A. No reliable changes in spleen cell number or lymphocyte subsets were found. These findings demonstrate that simply picking up an animal results in modulation of the immune response. These data are also of interest for their obvious methodological implications. © 1990.

引用

页码：1937 / 1944

页数：8

共 14 条

[1]

ADER R, 1965, PSYCHOL REP, V15, P535

[2]

ALTMAN J, 1968, Developmental Psychobiology, V1, P10, DOI 10.1002/dev.420010104

[3] THE ROLE OF HELPER T-CELL PRODUCTS IN MOUSE B-CELL DIFFERENTIATION AND ISOTYPE REGULATION [J].

COFFMAN, RL ;

SEYMOUR, BWP ;

LEBMAN, DA ;

HIRAKI, DD ;

CHRISTIANSEN, JA ;

SHRADER, B ;

CHERWINSKI, HM ;

SAVELKOUL, HFJ ;

FINKELMAN, FD ;

BOND, MW ;

MOSMANN, TR .

IMMUNOLOGICAL REVIEWS, 1988, 102 :5-28

[4]

FINKELMAN FD, 1988, J IMMUNOL, V140, P1022

[5] PSYCHOSOCIAL FACTORS MODIFYING HOST RESISTANCE TO EXPERIMENTAL INFECTIONS [J].

FRIEDMAN, SB ;

GLASGOW, LA ;

ADER, R .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1969, 164 (A2) :381-&

[6] EXPERIENTIAL AND ENVIRONMENTAL FACTORS IN CANCER - A REVIEW OF RESEARCH WITH ANIMALS [J].

LABARBA, RC .

PSYCHOSOMATIC MEDICINE, 1970, 32 (03) :259-&

[7]

LOWN B A, 1987, Brain Behavior and Immunity, V1, P356, DOI 10.1016/0889-1591(87)90039-0

[8] INFLUENCE OF EARLY MATERNAL-DEPRIVATION ON ADULT HUMORAL IMMUNE-RESPONSE IN MICE [J].

MICHAUT, RJ ;

DECHAMBRE, RP ;

DOUMERC, S ;

LESOURD, B ;

DEVILLECHABROLLE, A ;

MOULIAS, R .

PHYSIOLOGY & BEHAVIOR, 1981, 26 (02) :189-191

[9] THE KINETICS OF RECOVERY OF LEUKOCYTE NUMBER AND LYMPHOCYTE FUNCTION FOLLOWING AN INJECTION OF A SINGLE HIGH-DOSE OF CYCLOPHOSPHAMIDE IN C3H HEJ MICE [J].

MOYNIHAN, J ;

COHEN, N .

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 1989, 11 (05) :517-527

[10]

MOYNIHAN J, 1989, Brain Behavior and Immunity, V3, P90, DOI 10.1016/0889-1591(89)90008-1

← 1 2 →