CYTOTOXIC EFFECTS OF HEXAVALENT CHROMIUM IN CULTURED MURINE MACROPHAGES

被引：6

作者：

CHRISTENSEN, MM ^{[1
]}

ERNST, E ^{[1
]}

ELLERMANNERIKSEN, S ^{[1
]}

机构：

[1] AARHUS UNIV,INST ANAT,DEPT NEUROBIOL,DK-8000 AARHUS,DENMARK

来源：

ARCHIVES OF TOXICOLOGY | 1992年 / 66卷 / 05期

关键词：

HEXAVALENT CHROMIUM; MACROPHAGES; CELL SURVIVAL; PHAGOCYTOSIS; MIGRATION; MICE;

D O I：

10.1007/BF01973630

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The in vitro effect of hexavalent chromium (Cr(VI)) on mouse peritoneal macrophages was investigated. Our results demonstrate the existence of a threshold concentration of 2.5-mu-M of Cr(VI) above which chromium affects the viability of macrophages in a concentration dependent manner. Morphological changes were seen with increasing concentrations of chromium. Evidence is presented that protein production (virus-induced interferon) in murine peritoneal macrophages was impaired by hexavalent chromium at low concentrations, while random migration and phagocytic activity were only affected at high concentrations of Cr(VI).

引用

页码：347 / 353

页数：7

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