IMPAIRMENT OF FIBRINOLYSIS DURING THE GROWTH OF 2 MURINE MAMMARY ADENOCARCINOMAS

被引：23

作者：

ALONSO, DF

FARIAS, EF

JOFFE, EBD

机构：

[1] Research Department, Institute of Oncology Angel H. Roffo, University of Buenos Aires, 1417 Buenos Aires

来源：

CANCER LETTERS | 1993年 / 70卷 / 03期

关键词：

PLASMINOGEN ACTIVATORS; EUGLOBULINS; FIBRINOLYSIS; MAMMARY TUMORS; CANCER; MICE;

D O I：

10.1016/0304-3835(93)90229-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The fibrinolytic activity present in the euglobulin (EU) fraction of BALB/c mice before and during the growth of M3 and MM3 murine mammary adenocarcinomas was characterized. The main plasminogen activator (PA) form contained in EUs from control mice was defined as murine urokinase-type PA (uPA). Overall fibrinolytic activity decreased significantly during tumor development. Zymographies showed that this fall was associated with a reduction in the free uPA band (47 kDa) and to the detection of a tissue-type PA (tPA) complexed band (117 kDa). Western blotting showed free tPA protein (68 kDa) in control mice, that disappeared in M3 tumor-bearing mice. In this model, high subcutaneous tumor burden induces a severe impairment in the circulating fibrinolytic system.

引用

页码：181 / 187

页数：7

共 21 条

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