ROLE OF LEUKOTRIENES IN AIRWAY HYPERRESPONSIVENESS IN GUINEA-PIGS

被引：19

作者：

ISHIDA, K ^{[1
]}

THOMSON, RJ ^{[1
]}

SCHELLENBERG, RR ^{[1
]}

机构：

[1] UBC, ST PAULS HOSP, PULM RES LAB, 1081 BURRARD ST, VANCOUVER V6Z 1Y6, BC, CANADA

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1993年 / 108卷 / 03期

关键词：

AIRWAY HYPERRESPONSIVENESS; ASTHMA; LEUKOTRIENES; EOSINOPHILIA;

D O I：

10.1111/j.1476-5381.1993.tb12864.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 Repeated aerosolization of leukotriene C4 (LTC4) to guinea-pigs produced leftward shift in their pulmonary resistance (R(L)) dose-response curves to inhaled acetylcholine (ACh) without increasing the maximum responses. 2 Repeated LTC4 aerosolization did not increase airway eosinophils. 3 The 5-lipoxygenase-activating protein (FLAP) inhibitor, MK-886, prevented the leftward shift in R(L) dose-response curves to ACh following repeated antigen challenge in guinea-pigs. 4 MK-886 did not inhibit the increased maximal R(L) produced by repeated antigen challenge, nor inhibit the airway eosinophilia induced by repeated antigen challenge. 5 Our findings suggest that leukotrienes may account for the leftward shift in pulmonary resistance responses caused by antigen but do not cause the airway eosinophilia nor enhanced maximum bronchoconstrictor response to antigen.

引用

页码：700 / 704

页数：5

共 32 条

[1] ABNORMALITIES IN AIRWAY SMOOTH-MUSCLE IN FATAL ASTHMA [J].

BAI, TR ;

PRASAD, FW .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 141 (03) :552-557

[2] COMPARATIVE EFFECTS OF INHALED LEUKOTRIENE-C4, LEUKOTRIENE-D4, AND HISTAMINE IN NORMAL HUMAN-SUBJECTS [J].

BARNES, NC ;

PIPER, PJ ;

COSTELLO, JF .

THORAX, 1984, 39 (07) :500-504

[3] DIRECT EVIDENCE OF A ROLE FOR MAST-CELLS IN THE PATHOGENESIS OF ANTIGEN-INDUCED BRONCHOCONSTRICTION [J].

CASALE, TB ;

WOOD, D ;

RICHERSON, HB ;

ZEHR, B ;

ZAVALA, D ;

HUNNINGHAKE, GW .

JOURNAL OF CLINICAL INVESTIGATION, 1987, 80 (05) :1507-1511

[4] LEUKOTRIENES ARE POTENT CONSTRICTORS OF HUMAN BRONCHI [J].

DAHLEN, SE ;

HEDQVIST, P ;

HAMMARSTROM, S ;

SAMUELSSON, B .

NATURE, 1980, 288 (5790) :484-486

[5] LEUKOTRIENES PROMOTE PLASMA LEAKAGE AND LEUKOCYTE ADHESION IN POST-CAPILLARY VENULES - INVIVO EFFECTS WITH RELEVANCE TO THE ACUTE INFLAMMATORY RESPONSE [J].

DAHLEN, SE ;

BJORK, J ;

HEDQVIST, P ;

ARFORS, KE ;

HAMMARSTROM, S ;

LINDGREN, JA ;

SAMUELSSON, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (06) :3887-3891

[6] ALLERGEN CHALLENGE OF LUNG-TISSUE FROM ASTHMATICS ELICITS BRONCHIAL CONTRACTION THAT CORRELATES WITH THE RELEASE OF LEUKOTRIENE-C4, LEUKOTRIENE-D4, AND LEUKOTRIENE-E4 [J].

DAHLEN, SE ;

HANSSON, G ;

HEDQVIST, P ;

BJORCK, T ;

GRANSTROM, E ;

DAHLEN, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (06) :1712-1716

[7]

DEJONGSTE JC, 1987, EUR J RESPIR DIS, V71, P23

[8] REQUIREMENT OF A 5-LIPOXYGENASE-ACTIVATING PROTEIN FOR LEUKOTRIENE SYNTHESIS [J].

DIXON, RAF ;

DIEHL, RE ;

OPAS, E ;

RANDS, E ;

VICKERS, PJ ;

EVANS, JF ;

GILLARD, JW ;

MILLER, DK .

NATURE, 1990, 343 (6255) :282-284

[9] FAMILIES OF LINES - RANDOM EFFECTS IN LINEAR-REGRESSION ANALYSIS [J].

FELDMAN, HA .

JOURNAL OF APPLIED PHYSIOLOGY, 1988, 64 (04) :1721-1732

[10]

Fleiss J., 1985, DESIGN ANAL CLIN EXP

← 1 2 3 4 →