PROTECTIVE ACTIONS OF TAMOXIFEN AND 4-HYDROXYTAMOXIFEN AGAINST OXIDATIVE DAMAGE TO HUMAN LOW-DENSITY LIPOPROTEINS - A MECHANISM ACCOUNTING FOR THE CARDIOPROTECTIVE ACTION OF TAMOXIFEN

被引：71

作者：

WISEMAN, H ^{[1
]}

PAGANGA, G ^{[1
]}

RICEEVANS, C ^{[1
]}

HALLIWELL, B ^{[1
]}

机构：

[1] UNITED MED SCH GUYS & ST THOMASS HOSP, GUYS HOSP, DIV BIOCHEM, LONDON SE1 9RT, ENGLAND

来源：

BIOCHEMICAL JOURNAL | 1993年 / 292卷

关键词：

D O I：

10.1042/bj2920635

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tamoxifen and 4-hydroxytamoxifen protect isolated human low-density lipoproteins (LDLs) against copper-ion-dependent lipid peroxidation: 4-hydroxytamoxifen is more protective than tamoxifen or 17beta-oestradiol. 4-Hydroxytamoxifen and 17beta-oestradiol also prevent the increase in the electrophoretic mobility of LDL caused by exposure to copper ions, presumably by protection of the apoprotein B of LDL against oxidative modification. Our observations may help to account for the cardioprotective benefits reported to be associated with tamoxifen therapy and prophylaxis in breast cancer.

引用

页码：635 / 638

页数：4

共 35 条

[1] RESULTS OF THE CANCER-RESEARCH CAMPAIGN ADJUVANT TRIAL FOR PERIOPERATIVE CYCLOPHOSPHAMIDE AND LONG-TERM TAMOXIFEN IN EARLY BREAST-CANCER REPORTED AT THE 10TH YEAR OF FOLLOW-UP [J].

BAUM, M ;

HOUGHTON, J ;

RILEY, D ;

MACINTYRE, J ;

BERSTOCK, D ;

MCKINNA, A ;

JACKSON, I ;

SAINSBURY, JRC ;

WILSON, A ;

WHEELER, T ;

DOBBS, J ;

REES, G ;

POWLES, T ;

RUBENS, R ;

HAYBRITTLE, J ;

MCPHERSON, K ;

HOUGHTON, J .

ACTA ONCOLOGICA, 1992, 31 (02) :251-257

[2] PROSPECTS FOR THE PRIMARY PREVENTION OF BREAST-CANCER [J].

BERNSTEIN, L ;

ROSS, RK ;

HENDERSON, BE .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1992, 135 (02) :142-152

[3]

BUTTA A, 1992, CANCER RES, V52, P4261

[4]

CHUNG BH, 1980, J LIPID RES, V21, P284

[5] LONG-TERM EFFECTS OF TAMOXIFEN ON BLOOD LIPID VALUES IN BREAST-CANCER [J].

DEWAR, JA ;

HOROBIN, JM ;

PREECE, PE ;

TAVENDALE, R ;

TUNSTALLPEDOE, H ;

WOOD, RAB .

BRITISH MEDICAL JOURNAL, 1992, 305 (6847) :225-226

[6] THE ROLE OF LIPID-PEROXIDATION AND ANTIOXIDANTS IN OXIDATIVE MODIFICATION OF LDL [J].

ESTERBAUER, H ;

GEBICKI, J ;

PUHL, H ;

JURGENS, G .

FREE RADICAL BIOLOGY AND MEDICINE, 1992, 13 (04) :341-390

[7] CONTINUOUS MONITORING OF INVITRO OXIDATION OF HUMAN LOW-DENSITY LIPOPROTEIN [J].

ESTERBAUER, H ;

STRIEGL, G ;

PUHL, H ;

ROTHENEDER, M .

FREE RADICAL RESEARCH COMMUNICATIONS, 1989, 6 (01) :67-75

[8] PROSPECTIVE CONTROLLED TRIAL WITH ANTIESTROGEN DRUG TAMOXIFEN IN PATIENTS WITH UNRESECTABLE HEPATOCELLULAR-CARCINOMA [J].

FARINATI, F ;

DEMARIA, N ;

FORNASIERO, A ;

SALVAGNINI, M ;

FAGIUOLI, S ;

CHIARAMONTE, M ;

NACCARATO, R .

DIGESTIVE DISEASES AND SCIENCES, 1992, 37 (05) :659-662

[9]

HAMILTON C, 1992, INTRO NEW TREATMENTS, P315

[10] EFFECT OF 17 BETA ESTRADIOL ON AORTIC CHOLESTEROL CONTENT AND METABOLISM IN CHOLESTEROL-FED RABBITS [J].

HOUGH, JL ;

ZILVERSMIT, DB .

ARTERIOSCLEROSIS, 1986, 6 (01) :57-63

← 1 2 3 4 →