AN ANTIBODY AGAINST A CFTR-DERIVED SYNTHETIC PEPTIDE, INCORPORATED INTO LIVING SUBMANDIBULAR CELLS, INHIBITS BETA-ADRENERGIC STIMULATION OF MUCIN SECRETION

被引：36

作者：

MILLS, CL

PEREIRA, MMC

DORMER, RL

MCPHERSON, MA

机构：

[1] Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, CF4 4XN, Heath Park

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 188卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)91351-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An antibody raised against a peptide in the first nucleotide-binding domain (NBD) of CFTR [1], incorporated into intact rat submandibular acini by hypotonic swelling, inhibited beta-adrenergic stimulated mucin secretion, without affecting cyclic AMP rise. The data are the first to show that a CFTR-antibody-containing cell results in defective stimulation of mucin secretion, as is seen in CF cells, and that this can be reversed by an excessive increase in cyclic AMP. © 1992.

引用

收藏

页码：1146 / 1152

页数：7

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