OPPOSITE EFFECTS OF CYCLOHEXYLADENOSINE AND THEOPHYLLINE ON HYPOXIC DAMAGE IN CULTURED NEURONS

被引：18

作者：

DAVAL, JL

NICOLAS, F

机构：

[1] INSERM U.272, Université de Nancy I, 54013 Nancy, BP 3069

来源：

NEUROSCIENCE LETTERS | 1994年 / 175卷 / 1-2期

关键词：

CULTURED NEURON; HYPOXIA; LACTATE DEHYDROGENASE EFFLUX; DEOXYGLUCOSE TRANSPORT; CYCLOHEXYLADENOSINE; THEOPHYLLINE;

D O I：

10.1016/0304-3940(94)91092-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To study the central effects of adenosine on hypoxia, the influence of treatment by the A, receptor agonist cyclohexyladenosine (1 mu M) or by the antagonist theophylline (10 mu M) was tested on cell damage in a model of neuronal culture. Whereas theophylline enhanced cell injury induced by 8 h hypoxia, cyclohexyladenosine decreased lactate dehydrogenase leakage, abolished the transient increase in 2-D-deoxyglucose transport and improved cell morphology. Such actions might involve regulation of excitatory amino acid release and maintenance of calcium homeostasis.

引用

页码：114 / 116

页数：3

共 17 条

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