THE HUMAN PAPILLOMAVIRUS STATUS OF INVASIVE CERVICAL ADENOCARCINOMA - A CLINICOPATHOLOGICAL AND OUTCOME ANALYSIS

被引:51
作者
DUGGAN, MA
MCGREGOR, SE
BENOIT, JL
INOUE, M
NATION, JG
STUART, GCE
机构
[1] FOOTHILLS PROV GEN HOSP,DEPT OBSTET & GYNECOL,CALGARY,AB T2N 2T9,CANADA
[2] UNIV CALGARY,CALGARY,AB,CANADA
[3] TOM BAKER CANC CLIN,DIV EPIDEMIOL & PREVENT ONCOL,CALGARY,AB,CANADA
关键词
CERVICAL ADENOCARCINOMA; HUMAN PAPILLOMAVIRUS; RISK AND PROGNOSTIC FACTORS;
D O I
10.1016/0046-8177(95)90065-9
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Accumulating evidence highlights the human papillomavirus (HPV) as a risk factor for cervical adenocarcinoma. However, the part played by the HPV in predicting tumor outcome or the increasing frequency of cervical adenocarcinoma is incompletely studied. In a retrospective study the association between HPV status and the clinicopathological characteristics of 77 cases of cervical adenocarcinoma Tvas investigated. The data were then analyzed for temporal differences in HPV status and to identify outcome predictors. Human papillomavirus status was determined by dot blot hybridization using probes for HPV 6, 11, 16, 18, 31, 33, and 35, followed by polymerase chain reaction amplification of the dot blot negative cases. Seven type-specific and consensus HPV primers were used. Human papillomavirus type 16, 18, or 33 was present in 53 (70%) cases. Human papillomavirus status did not correlate with disease outcome or any clinicopathological variable, except that tumors presenting in and after 1981 were more frequently HPV positive than those presenting before 1981 (P = .014). In a multivariate analysis only clinical stage at presentation was predictive of disease outcome. Because temporal differences in clinicopathological characteristics were not identified, the increasing frequency of cervical adenocarcinoma may relate to a more important oncogenic role for the HPV in tumors presenting after 1980. Copyright (C) 1995 by W.B. Saunders Company
引用
收藏
页码:319 / 325
页数:7
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