INVOLVEMENT OF THE CYTOSKELETON IN THE MECHANISM OF ACTION OF ENDOTHELIN ON FROG ADRENOCORTICAL-CELLS

被引:13
作者
REMYJOUET, I [1 ]
DELARUE, C [1 ]
FEUILLOLEY, M [1 ]
VAUDRY, H [1 ]
机构
[1] UNIV ROUEN,EUROPEAN INST PEPTIDE RES,CELLULAR & MOLEC NEUROENDOCRINOL LAB,CNRS,UA,INSERM 4413,F-76821 MONT ST AIGNAN,FRANCE
关键词
D O I
10.1016/0960-0760(94)90172-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In a previous report, we have shown that endothelin-1 (ET-1) is a potent stimulator of corticosterone and aldosterone secretion by frog adrenocortical cells. In the present study, we examine the possible involvement of cytoskeletal elements in the mechanism of action of ET-1 on corticosteroid secretion from frog adrenal gland. The microfilament disrupting agent cytochalasin B (5 x 10(-5) M) induced a reversible inhibition of the spontaneous secretion of corticosteroid and blocked the response of adrenocortical cells to ET-1 (5 x 10(-9) M). In contrast, the antimicrotubular agent vinblastine (10(-5) M) and the intermediate filament inhibitor beta-beta' iminodipropionitrile (10(-3) M) had virtually no effect on both spontaneous and endothelin-induced steroidogenesis. Taken together, these results indicate that, in the frog adrenal gland, the integrity of the microfilament network is required for the corticotropic activity of ET-1 whereas microtubules and intermediate filaments are apparently not involved in the mechanism of action of ET-1.
引用
收藏
页码:55 / 59
页数:5
相关论文
共 28 条
[1]  
CARSIA RV, 1987, P SOC EXP BIOL MED, V184, P461
[2]  
CRIVELLO JF, 1980, J BIOL CHEM, V255, P8144
[3]   EFFECTS OF CYTOCHALASIN-B AND VINBLASTINE ON MOVEMENT OF CHOLESTEROL IN RAT ADRENAL-GLANDS [J].
CRIVELLO, JF ;
JEFCOATE, CR .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1979, 89 (04) :1127-1134
[4]  
CRONSHAW J, 1984, CELL TISSUE RES, V236, P333
[5]   INVITRO EFFECT OF PROSTAGLANDINS ON CORTICOSTERONE AND ALDOSTERONE PRODUCTION BY FROG INTERRENAL GLAND [J].
DELARUE, C ;
PERROTEAU, I ;
LEBOULENGER, F ;
NETCHITAILO, P ;
LEROUX, P ;
JEGOU, S ;
BELANGER, A ;
TONON, MC ;
VAUDRY, H .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1981, 100 (02) :769-777
[6]   ENDOTHELIN STIMULATES STEROID-SECRETION BY FROG ADRENAL-GLAND INVITRO - EVIDENCE FOR THE INVOLVEMENT OF PROSTAGLANDINS AND EXTRACELLULAR CALCIUM IN THE MECHANISM OF ACTION OF ENDOTHELIN [J].
DELARUE, C ;
DELTON, I ;
FIORINI, F ;
HOMODELARCHE, F ;
FASOLO, A ;
BRAQUET, P ;
VAUDRY, H .
ENDOCRINOLOGY, 1990, 127 (04) :2001-2008
[7]   SEROTONIN STIMULATES CORTICOSTEROID SECRETION BY FROG ADRENOCORTICAL TISSUE INVITRO [J].
DELARUE, C ;
LEFEBVRE, H ;
IDRES, S ;
LEBOULENGER, F ;
HOMODELARCHE, G ;
LIHRMANN, I ;
FEUILLOLEY, M ;
VAUDRY, H .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1988, 29 (05) :519-525
[8]   EFFECT OF VINBLASTINE, A POTENT ANTIMICROTUBULAR AGENT ON STEROID-SECRETION BY PERIFUSED FROG ADRENAL-GLANDS [J].
FEUILLOLEY, M ;
NETCHITAILO, P ;
LIHRMANN, I ;
VAUDRY, H .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1986, 25 (01) :143-147
[9]   EFFECT OF CYTOCHALASIN-B ON THE METABOLISM OF POLYPHOSPHOINOSITIDES IN ADRENOCORTICAL-CELLS [J].
FEUILLOLEY, M ;
DESRUES, L ;
VAUDRY, H .
ENDOCRINOLOGY, 1993, 133 (05) :2319-2326
[10]   INVOLVEMENT OF THE CYTOSKELETON IN THE STEROIDOGENIC RESPONSE OF FROG ADRENAL-GLANDS TO ANGIOTENSIN-II, ACETYLCHOLINE AND SEROTONIN [J].
FEUILLOLEY, M ;
NETCHITAILO, P ;
DELARUE, C ;
LEBOULENGER, F ;
BENYAMINA, M ;
PELLETIER, G ;
VAUDRY, H .
JOURNAL OF ENDOCRINOLOGY, 1988, 118 (03) :365-&