EFFECTS OF STANOZOLOL AND L-CARNITINE ON ERYTHROCYTE OSMOTIC FRAGILITY DURING AEROBIC EXERCISE IN RATS

被引：3

作者：

BAYON, JE ^{[1
]}

ALVAREZ, AI ^{[1
]}

BARRIO, JP ^{[1
]}

DIEZ, C ^{[1
]}

PRIETO, JG ^{[1
]}

机构：

[1] FAC VET LEON,DEPT FISIOL FARMACOL & TOXICOL,E-24071 LEON,SPAIN

来源：

COMPARATIVE HAEMATOLOGY INTERNATIONAL | 1993年 / 3卷 / 04期

关键词：

ANABOLIC AGENTS; HEMOLYSIS L-CARNITINE; OSMOTIC FRAGILITY; RAT; STANOZOLOL;

D O I：

10.1007/BF02341966

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect on erythrocyte osmotic fragility of two anabolic agents, widely used to improve physical performance, has been studied. These agents, the steroid derivative, stanozolol, and a quaternary amine, L-carnitine, were administered to rats at rest and while performing running exercises, for 12 weeks. The results show that exercise does not alter the haemolysis curve. Administration of both agents in resting condition does increase the osmotic resistance of the erythrocytes. The combined effect of drug administration and physical exercise further increases the osmotic resistance in the case of stanozolol, presumably due to the steroid-erythrocyte membrane interaction as well as by an erthyropoietic effect.

引用

页码：196 / 200

页数：5

共 31 条

[1] DANAZOL THERAPY RENDERS RED-CELLS RESISTANT TO OSMOTIC LYSIS [J].

AHN, YS ;

FERNANDEZ, LF ;

KIM, CI ;

MYLVAGANAM, R ;

TEMPLE, JD ;

CAYER, ML ;

HARRINGTON, WJ .

FASEB JOURNAL, 1989, 3 (02) :157-162

[2]

Alen M, 1985, Br J Sports Med, V19, P15

[3]

ALVERTAZZI A, 1982, P EUR DIAL TRANSPLAN, V19, P302

[4]

AVAKUMOV VM, 1988, KHIM FARM ZH+, V22, P379

[5] A COMPARISON OF BODY AND ORGAN WEIGHTS, PHYSIOLOGIC PARAMETERS, AND PATHOLOGIC-CHANGES IN TARGET ORGANS OF RATS GIVEN COMBINATIONS OF EXERCISE, ANABOLIC HORMONE, AND PROTEIN SUPPLEMENTATION [J].

BAUMAN, DH ;

RICHERSON, JT ;

BRITT, AL .

AMERICAN JOURNAL OF SPORTS MEDICINE, 1988, 16 (04) :397-402

[6]

BOBYLEVAGUARRIERO V, 1988, J SPORT MED PHYS FIT, V28, P298

[7]

BORUM PR, 1986, J AM DIET ASSOC, V86, P644

[8]

CARLIN JI, 1983, J APPL PHYSIOL, V55, P489

[9] ANABOLIC STEROID STANOZOLOL ITS EVALUATION IN DEBILITATED CHILDREN [J].

CARTER, CH .

CLINICAL PEDIATRICS, 1965, 4 (11) :671-&

[10] LIPID ABNORMALITIES IN UREMIA, DIALYSIS, AND TRANSPLANTATION [J].

CHAN, MK ;

VARGHESE, Z ;

MOORHEAD, JF .

KIDNEY INTERNATIONAL, 1981, 19 (05) :625-637

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