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TH1 VERSUS TH2 RESPONSES IN AIDS

被引：46
作者：
ROMAGNANI, S
MAGGI, E
机构：
[1] University of Florence, Florence
来源：
CURRENT OPINION IN IMMUNOLOGY | 1994年 / 6卷 / 04期
关键词：
D O I：
10.1016/0952-7915(94)90150-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
During the past two years, a simple theory that seeks to explain what causes the progression of HIV-infected individuals to AIDS has been gaining support. The theory holds that HIV-infected people switch from a T-helper type 1 (Th1) to a T-helper type 2 (Th2) state as the disease progresses. However the experimental data do not support the concept that a Th1/7h2 switch occurs in the majority of H1V-infected subjects, although it is conceivable that HIV-infected individuals who mount sustained and chronic Th2-type responses, as a result of allergic disorders and helminthic infestations, may undergo more active HIV replication and therefore progress faster to full-blown disease.
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收藏
页码：616 / 622
页数：7
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