AUTOANTIBODIES-LIKE ANTIGEN-BINDING CHARACTERISTICS OF INDUCED ANTIBODIES AGAINST POLYLYSINE-POLYGLUTAMATE COMPLEX

被引：9

作者：

ARIF, Z ^{[1
]}

ARJUMAND, S ^{[1
]}

ALI, A ^{[1
]}

ALI, R ^{[1
]}

机构：

[1] ALIGARH MUSLIM UNIV,FAC MED,DEPT BIOCHEM,ALIGARH 202002,UTTAR PRADESH,INDIA

来源：

AUTOIMMUNITY | 1994年 / 19卷 / 01期

关键词：

AUTOANTIBODIES; ANTI-DNA ANTIBODIES; SYSTEMIC LUPUS ERYTHEMATOSUS; POLYLYSINE POLYGLUTAMATE;

D O I：

10.3109/08916939409008003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rabbits immunized with polylysine-polyglutamate complex induced high titer antibodies. The immune IgG exhibited high degree of specificity towards the immunogen. In a competition assay, nDNA, heat denatured DNA and total buffalo thymus RNA were inhibitory. An appreciable binding with polyglutamate, poly(rG).poly(dC).poly(dG).poly(dC), cardiolipin, poly(dA-dU). Poly(dA-dU) and Z-or Z-like conformations demonstrates the polyspecificity of induced antibodies. The immunological specificity of induced antibodies was comparable to autoantibodies derived from SLE. The results might be of some help in understanding the etiology of autoimmune process.

引用

页码：7 / 14

页数：8

共 40 条

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