ESTIMATION OF THE PORE-SIZE AND CHARGE-DENSITY IN HUMAN CADAVER SKIN

被引:52
作者
AGUILELLA, V
KONTTURI, K
MURTOMAKI, L
RAMIREZ, P
机构
[1] HELSINKI UNIV TECHNOL,DEPT CHEM ENGN,PHYS CHEM & ELECTROCHEM LAB,SF-02150 ESPOO,FINLAND
[2] UNIV JAUME 1,DEPT EXPTL SCI,E-12071 CASTELLO DE PLANA,SPAIN
关键词
STREAMING POTENTIAL; TRANSPORT NUMBER; HUMAN SKIN; AQUEOUS PORE SIZE; PORE SIZE DISTRIBUTION;
D O I
10.1016/0168-3659(94)90235-6
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Streaming potential and the cation transport number were measured in human cadaver skin. The transport number was used to estimate the charge density in aqueous pores of skin using both Donnan equilibrium and Langmuir adsorption isotherm. A microscopic model was employed to evaluate the pore radius from the streaming potential and charge density data. The capillary pore model was extended to account for any distribution of pore size, and applied particularly to the gaussian distribution. The mean radius of the distribution appeared to be slightly less than that of the single pore model. In both cases the radii were ca. 20 nm.
引用
收藏
页码:249 / 257
页数:9
相关论文
共 25 条
[1]  
ANDERSEN OS, 1978, MEMBRANE TRANSPORT B, V1, P369
[2]   CHARACTERIZATION OF THE PERMSELECTIVE PROPERTIES OF EXCISED HUMAN-SKIN DURING IONTOPHORESIS [J].
BURNETTE, RR ;
ONGPIPATTANAKUL, B .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1987, 76 (10) :765-773
[3]   VISUALIZATION OF IONTOPHORETIC PATHWAYS WITH CONFOCAL MICROSCOPY AND THE VIBRATING PROBE ELECTRODE [J].
CULLANDER, C ;
GUY, RH .
SOLID STATE IONICS, 1992, 53 :197-206
[4]   IONTOPHORETIC DELIVERY OF A SERIES OF TRIPEPTIDES ACROSS THE SKIN INVITRO [J].
GREEN, PG ;
HINZ, RS ;
KIM, A ;
SZOKA, FC ;
GUY, RH .
PHARMACEUTICAL RESEARCH, 1991, 8 (09) :1121-1127
[5]   SKIN IMPEDANCE AND ELECTROOSMOSIS IN THE HUMAN-EPIDERMIS [J].
GRIMNES, S .
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 1983, 21 (06) :739-749
[6]  
Hunter R.J., 1981, ZETA POTENTIAL COLLO, DOI [10.1016/c2013-0-07389-6, 10.1016/j.berh.2014.02.004]
[7]   THEORETICAL-MODELS FOR IONTOPHORETIC DELIVERY [J].
KASTING, GB .
ADVANCED DRUG DELIVERY REVIEWS, 1992, 9 (2-3) :177-199
[8]   APPLICATION OF ELECTRODIFFUSION THEORY FOR A HOMOGENEOUS MEMBRANE TO IONTOPHORETIC TRANSPORT THROUGH SKIN [J].
KASTING, GB ;
KEISTER, JC .
JOURNAL OF CONTROLLED RELEASE, 1989, 8 (03) :195-210
[9]   STUDY OF ADSORPTION AND ION-EXCHANGE PROPERTIES OF SOME POROUS MEMBRANES [J].
KONTTURI, K ;
SAVONEN, A ;
VUORISTO, M .
ACTA CHEMICA SCANDINAVICA, 1994, 48 (01) :1-11
[10]  
LAKSHMINARAYANA.N, 1969, TRANSPORT PHENOMENA