MEMBRANE-CHANGES IN POLYMORPHONUCLEAR LEUKOCYTES DURING IONOPHORE (A23187)-INDUCED LYSOSOMAL RELEASE

被引：10

作者：

MOORE, PL ^{[1
]}

BANK, HL ^{[1
]}

SANNES, PL ^{[1
]}

SPICER, SS ^{[1
]}

机构：

[1] MED UNIV S CAROLINA, DEPT PATHOL, CHARLESTON, SC 29403 USA

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 1979年 / 30卷 / 03期

关键词：

D O I：

10.1016/0014-4800(79)90094-7

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Micromolar concentrations of the divalent ionophore A23187 and millimolar concentrations of extracellular Ca caused the rapid exocytosis of lysosomes from rabbit polymorphonuclear leukocytes. In control experiments the larger granules remained within the leukocytes, while another class of smaller granules fused with the plasma membrane. Whenever membrane fusion and exocytosis occurred, intramembranous particle-free regions developed within the plasma membrane at the sites of fusion. Neither a massive aggregation of intramembranoous particles (IMP), nor the formation of highly symmetrical rosette patterns of IMP was seen in either experimental or control preparations.

引用

页码：420 / 433

页数：14

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