THE ROLE OF OPERATOR POSITION IN SV40 T-ANTIGEN-MEDIATED REPRESSION

被引：4

作者：

COX, M ^{[1
]}

RYDER, K ^{[1
]}

SILVER, S ^{[1
]}

TEGTMEYER, P ^{[1
]}

机构：

[1] SUNY STONY BROOK, DEPT MICROBIOL, STONY BROOK, NY 11794 USA

来源：

VIROLOGY | 1988年 / 167卷 / 01期

关键词：

D O I：

10.1016/0042-6822(88)90082-7

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have manipulated positional relationships between the SV40 early operator and promoter to study the repression of transcription by T antigen. Single or multiple insertions of T-antigen-binding region I resulted in only weak repression even when the operator was placed immediately adjacent to known promoter elements. The low levels of repression appear to reflect the intrinsic strength of the T-antigen-operator interaction.

引用

页码：293 / 295

页数：3

共 18 条

[1] ATP STIMULATES THE BINDING OF SIMIAN VIRUS-40 (SV40) LARGE TUMOR-ANTIGEN TO THE SV40 ORIGIN OF REPLICATION
BOROWIEC, JA
HURWITZ, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (01) : 64 - 68
[2] IAC REPRESSOR CAN REGULATE EXPRESSION FROM A HYBRID-SV40 EARLY PROMOTER CONTAINING A LAC OPERATOR IN ANIMAL-CELLS
BROWN, M
FIGGE, J
HANSEN, U
WRIGHT, C
JEANG, KT
KHOURY, G
LIVINGSTON, DM
ROBERTS, TM
[J]. CELL, 1987, 49 (05) : 603 - 612
[3] THE ADENINE-THYMINE DOMAIN OF THE SIMIAN VIRUS-40 CORE ORIGIN DIRECTS DNA BENDING AND COORDINATELY REGULATES DNA-REPLICATION
DEB, S
DELUCIA, AL
KOFF, A
TSUI, S
TEGTMEYER, P
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (12) : 4578 - 4584
[4] ATP ENHANCES THE BINDING OF SIMIAN VIRUS-40 LARGE T-ANTIGEN TO THE ORIGIN OF REPLICATION
DEB, SP
TEGTMEYER, P
[J]. JOURNAL OF VIROLOGY, 1987, 61 (12) : 3649 - 3654
[5] REGULATORY MUTANTS OF SIMIAN VIRUS-40 - EFFECT OF MUTATIONS AT A T-ANTIGEN BINDING-SITE ON DNA-REPLICATION AND EXPRESSION OF VIRAL GENES
DIMAIO, D
NATHANS, D
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1982, 156 (03) : 531 - 548
[6] RECOMBINANT GENOMES WHICH EXPRESS CHLORAMPHENICOL ACETYLTRANSFERASE IN MAMMALIAN-CELLS
GORMAN, CM
MOFFAT, LF
HOWARD, BH
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1982, 2 (09) : 1044 - 1051
[7] T-ANTIGEN REPRESSION OF SV40 EARLY TRANSCRIPTION FROM 2 PROMOTERS
HANSEN, U
TENEN, DG
LIVINGSTON, DM
SHARP, PA
[J]. CELL, 1981, 27 (03) : 603 - 612
[8] THE INDUCIBLE IAC OPERATOR-REPRESSOR SYSTEM IS FUNCTIONAL IN MAMMALIAN-CELLS
HU, MCT
DAVIDSON, N
[J]. CELL, 1987, 48 (04) : 555 - 566
[9] TRANSCRIPTIONAL SELECTIVITY OF VIRAL GENES IN MAMMALIAN-CELLS
MCKNIGHT, S
TJIAN, R
[J]. CELL, 1986, 46 (06) : 795 - 805
[10] SV40 GENE-EXPRESSION IS MODULATED BY THE COOPERATIVE BINDING OF T-ANTIGEN TO DNA
MYERS, RM
RIO, DC
ROBBINS, AK
TJIAN, R
[J]. CELL, 1981, 25 (02) : 373 - 384

← 1 2 →