INVITRO INHIBITION OF BACTERIAL-DNA GYRASE BY CINODINE, A GLYCOCINNAMOYLSPERMIDINE ANTIBIOTIC

被引：27

作者：

OSBURNE, MS

MAIESE, WM

GREENSTEIN, M

机构：

[1] Lederle Laboratories, Medical Research Division, American Cyanamid Company, Pearl River

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 07期

关键词：

D O I：

10.1128/AAC.34.7.1450

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cinodine, a broad-spectrum glycocinnamoylspermidine antibiotics, binds to DNA and irreversibly inhibits bacterial and phage DNA synthesis. Cinodine was found to inhibit the activity of Micrococcus luteus DNA gyrase in vitro, but it did not inhibit the activities of two other DNA-binding enzymes, namely, topoisomerase I and BamHI. Although we cannot yet conclude that DNA gyrase is an intracellular target of the drug, in vitro inhibition of the enzyme by cinodine appears to be specific.

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页码：1450 / 1452

页数：3

相关论文

共 13 条

[1] DNA GYRASE AND THE SUPERCOILING OF DNA [J].

COZZARELLI, NR .

SCIENCE, 1980, 207 (4434) :953-960

[2] INHIBITORS OF DNA TOPOISOMERASES [J].

DRLICA, K ;

FRANCO, RJ .

BIOCHEMISTRY, 1988, 27 (07) :2253-2259

[3] GLYCOCINNAMOYLSPERMIDINES, A NEW CLASS OF ANTIBIOTICS .3. - STRUCTURES OF LL-BM123BETA, GAMMA1, AND GAMMA2 [J].

ELLESTAD, GA ;

COSULICH, DB ;

BROSCHARD, RW ;

MARTIN, JH ;

KUNSTMANN, MP ;

MORTON, GO ;

LANCASTER, JE ;

FULMOR, W ;

LOVELL, FM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (08) :2515-2524

[4] NALIDIXIC-ACID RESISTANCE - 2ND GENETIC CHARACTER INVOLVED IN DNA GYRASE ACTIVITY [J].

GELLERT, M ;

MIZUUCHI, K ;

ODEA, MH ;

ITOH, T ;

TOMIZAWA, JI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (11) :4772-4776

[5] DNA TOPOISOMERASES [J].

GELLERT, M .

ANNUAL REVIEW OF BIOCHEMISTRY, 1981, 50 :879-910

[6] NOVOBIOCIN AND COUMERMYCIN INHIBIT DNA SUPERCOILING CATALYZED BY DNA GYRASE [J].

GELLERT, M ;

ODEA, MH ;

ITOH, T ;

TOMIZAWA, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (12) :4474-4478

[7] MECHANISM OF ACTION OF CINODINE, A GLYCOCINNAMOYLSPERMIDINE ANTIBIOTIC [J].

GREENSTEIN, M ;

SPETH, JL ;

MAIESE, WM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1981, 20 (04) :425-432

[8] ESCHERICHIA-COLI MUTANTS THERMOSENSITIVE FOR DEOXYRIBONUCLEIC-ACID GYRASE SUBUNIT-A - EFFECTS ON DEOXYRIBONUCLEIC-ACID REPLICATION, TRANSCRIPTION, AND BACTERIOPHAGE GROWTH [J].

KREUZER, KN ;

COZZARELLI, NR .

JOURNAL OF BACTERIOLOGY, 1979, 140 (02) :424-435

[9] GLYCOCINNAMOYLSPERMIDINES - NEW CLASS OF ANTIBIOTICS .2. ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES OF LL-BM123-BETA, GAMMA-1 AND GAMMA-2 [J].

MARTIN, JH ;

KUNSTMANN, MP ;

BARBATSCHI, F ;

HERTZ, M ;

ELLESTAD, GA ;

DANN, M ;

REDIN, GS ;

DORNBUSH, AC ;

KUCK, NA .

JOURNAL OF ANTIBIOTICS, 1978, 31 (05) :398-404

[10]

OTTER R, 1983, METHOD ENZYMOL, V100, P171