INHIBITION BY ETHAMBUTOL OF MYCOLIC ACID TRANSFER INTO THE CELL-WALL OF MYCOBACTERIUM-SMEGMATIS

被引：90

作者：

TAKAYAMA, K

ARMSTRONG, EL

KUNUGI, KA

KILBURN, JO

机构：

[1] UNIV WISCONSIN, INST ENZYME RES, MADISON, WI 53706 USA

[2] CTR DIS CONTROL, BUR LABS, ATLANTA, GA 30333 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1979年 / 16卷 / 02期

关键词：

D O I：

10.1128/AAC.16.2.240

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ethambutol simultaneously inhibited the transfer (presumably via mycolyl acetyl trehalose) of mycolic acids into the cell wall and stimulated the synthesis of trehalose dimycolates of M. smegmatis. Structural similarities of the drug and mycolyl acetyl trehalose suggested that competitive inhibition was involved.

引用

收藏

页码：240 / 242

页数：3

相关论文

共 13 条

[1]

ASSELINEAU C, 1970, B SOC CHIM FR, P1455

[2] NONSPECIFIC IONIC INHIBITION OF ETHAMBUTOL BINDING BY MYCOBACTERIUM-SMEGMATIS [J].

BEGGS, WH ;

ANDREWS, FA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1973, 4 (02) :115-119

[3] EFFECT OF ETHAMBUTOL ON NUCLEIC ACID METABOLISM IN MYCOBACTERIUM SMEGMATIS AND ITS REVERSAL BY POLYAMINES AND DIVALENT CATIONS [J].

FORBES, M ;

KUCK, NA ;

PEETS, EA .

JOURNAL OF BACTERIOLOGY, 1965, 89 (05) :1299-&

[4]

KANTHER R, 1970, ANTIBIOT CHEMOTHER, V16, P203

[5]

KARLSON AG, 1961, AM REV RESPIR DIS, V84, P905

[6] EFFECT OF ETHAMBUTOL ON VIABLE CELL COUNT IN MYCOBACTERIUM-SMEGMATIS [J].

KILBURN, JO ;

GREENBERG, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1977, 11 (03) :534-540

[7] METABOLIC ROLE OF FREE MYCOLIC ACIDS IN MYCOBACTERIUM-TUBERCULOSIS [J].

TAKAYAMA, K ;

ARMSTRONG, EL .

JOURNAL OF BACTERIOLOGY, 1977, 130 (01) :569-570

[8] ISOLATION, CHARACTERIZATION, AND FUNCTION OF 6-MYCOLYL-6'-ACETYLTREHALOSE IN H37RA STRAIN OF MYCOBACTERIUM-TUBERCULOSIS [J].

TAKAYAMA, K ;

ARMSTRONG, EL .

BIOCHEMISTRY, 1976, 15 (02) :441-447

[9] EFFECT ON ISONIAZID ON IN-VIVO MYCOLIC ACID SYNTHESIS, CELL-GROWTH, AND VIABILITY OF MYCOBACTERIUM-TUBERCULOSIS [J].

TAKAYAMA, K ;

WANG, L ;

DAVID, HL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1972, 2 (01) :29-&

[10]

THOMAS JP, 1961, AM REV RESPIR DIS, V83, P891