PARTIAL SYNTHESIS OF 6'-HYDROXYCINCHONINE AND ITS ANTI-ARRHYTHMIC ACTIVITY IN MICE

被引：19

作者：

SMALL, LD

ROSENBERG, H

NWANGWU, PU

HOLCSLAW, TL

STOHS, SJ

机构：

[1] College of Pharmacy, University of Nebraska Medical Center, Omaha

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 08期

关键词：

D O I：

10.1021/jm00194a027

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of 6ʹ-hydroxycinchonine [(8fl, 9S)-cinchonan-6ʹ, 9-diol] was achieved by demethylating quinidine with boron tribromide in dichloromethane at -75°C. The antiarrhythmic activities of 6ʹ-hydroxycinchonine and quinidine were compared following the infusion of aconitine into the tail veins of mice to induce arrhythmias. Comparative ED50 and LD50 studies for quinidine and 6ʹ-hydroxycinchonine revealed equivalent antiarrhythmic potencies for the two drugs but a smaller acute toxicity for 6ʹ-hydroxycinchonine. © 1979, American Chemical Society. All rights reserved.

引用

页码：1014 / 1016

页数：3

共 11 条

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