1,3-DIPOLAR CYCLOADDITION REACTIONS OF VINYLCEPHALOSPORINS WITH DIAZOALKANES

被引：10

作者：

PITLIK, J ^{[1
]}

GUNDA, TE ^{[1
]}

MISKOLCZI, I ^{[1
]}

机构：

[1] BIOGAL PHARMACEUT WORKS,DEBRECEN,HUNGARY

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 05期

关键词：

D O I：

10.1002/jhet.5570270521

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The vinylcephalosporin (1) undergoes a regio‐ and stereoselective 1,3‐dipolar cycloaddition with diazomethane to give novel cephalosporins, a 3‐pyrazolinocephem (4) and a double adduct (5). The vinylcephalosporin sulphoxide (2) gives only the pyrazolinocephem (7). In the reaction with diphenyldiazomethane upon heating the initially formed pyrazolines decompose and cyclopropylcephalosporin (9) formation takes place. The determination of the structures and stereochemistry of these compounds is also described. Copyright © 1990 Journal of Heterocyclic Chemistry

引用

页码：1281 / 1285

页数：5

共 8 条

[1] CHEMISTRY OF CEPHALOSPORIN ANTIBIOTICS .6. CARBAMATE FORMATION IN AWUEOUS BICARBONATE SOLUTIONS OF 7-ACA [J].