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ENHANCED ANALGESIC EFFECTS OF STRESS FOLLOWING CHRONIC ADMINISTRATION OF NALTREXONE IN RATS

被引：28
作者：
AMIR, S
AMIT, Z
机构：
[1] Center for Research on Drug Dependence, Department of Psychology, Concordia University, Montréal, Que. H3G 1M8
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 59卷 / 1-2期
基金：
英国医学研究理事会;
关键词：
Chronic naltrexone; Hot-plate test; Opiate receptor supersensitivity; Stress-induced analgesia;
D O I：
10.1016/0014-2999(79)90036-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Chronic administration of the long acting opiate antagonist naltrexone potentiated the analgesic effects of foot-shock stress in the hot-plate test in rats. No changes in pain responsiveness were noted in naltrexone-treated rats that were not subjected to the foot-shock treatment. The results suggest that chronic opiate receptor may lead to the development of supersensitivity in endogenous opiate systems that mediate the analgesic effects of stress. © 1979.
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页码：137 / 140
页数：4
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