CLINICAL PHARMACOKINETICS OF ANXIOLYTICS AND HYPNOTICS IN THE ELDERLY - THERAPEUTIC CONSIDERATIONS .2.

被引：72

作者：

GREENBLATT, DJ

HARMATZ, JS

SHADER, RI

机构：

[1] NEW ENGLAND MED CTR HOSP,BOSTON,MA

[2] TUFTS UNIV,SCH MED,DEPT PSYCHIAT,DIV CLIN PHARMACOL,BOSTON,MA 02111

[3] TUFTS UNIV,SCH MED,DEPT PHARMACOL,BOSTON,MA 02111

[4] TUFTS UNIV,SCH MED,DEPT MED,BOSTON,MA 02111

来源：

CLINICAL PHARMACOKINETICS | 1991年 / 21卷 / 04期

关键词：

D O I：

10.2165/00003088-199121040-00003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Part I of this article, which appeared in the previous issue of the Journal, discussed the scope of and scientific basis for special pharmacokinetic studies of anxiolytic and hypnotic drugs in the elderly, and examined the methodology and results of such studies and the prediction of pharmacolinetic changes. In Part II the authors continue their review, focusing on age-related pharmacodynamic changes in the effects of these drugs, the attempts to correlate pharmacokinetic with pharmacodynamic findings, and the clinical applications of these data.

引用

页码：262 / 273

页数：12

共 165 条

[1]

AALTONEN L, 1982, ACTA PHARMACOL TOX, V51, P126

[2] PHARMACOKINETIC INVESTIGATIONS IN ELDERLY PATIENTS - CLINICAL AND ETHICAL CONSIDERATIONS [J].