CHELATING LIGANDS FUNCTIONALIZED FOR FACILE ATTACHMENT TO BIOMOLECULES - A CONVENIENT ROUTE TO 4-ISOTHIOCYANATOBENZYL DERIVATIVES OF DIETHYLENETRIAMINEPENTAACETIC ACID AND ETHYLENEDIAMINETETRAACETIC ACID

被引：40

作者：

KEANA, JFW

MANN, JS

机构：

[1] Department of Chemistry, University of Oregon, Eugene

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 09期

关键词：

D O I：

10.1021/jo00296a057

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compounds were synthesized by alkylation of the monoenolates of DTPA and EDTA permethyl esters 3 and 4 with benzyl bromide. The benzylated esters 5 and 6 were nitrated, hydrogenated, and converted to their isothiocyanate derivatives 13 and 14 in good yields. The Gd(III) complex of 4-(isothiocyanatobenzyl)-DTPA 16, a potential contrast-enhancing agent for magnetic resonance imaging (MRI), was prepared. © 1990, American Chemical Society. All rights reserved.

引用

页码：2868 / 2871

页数：4

共 20 条

[1] SYNTHESIS OF 1-(PARA-ISOTHIOCYANATOBENZYL) DERIVATIVES OF DTPA AND EDTA - ANTIBODY LABELING AND TUMOR-IMAGING STUDIES [J].