ADMINISTRATION OF IL-2-PE40 VIA OSMOTIC PUMPS PREVENTS ADJUVANT INDUCED ARTHRITIS IN RATS - IMPROVED THERAPEUTIC INDEX OF IL-2-PE40 ADMINISTERED BY CONTINUOUS INFUSION

被引：14

作者：

LORBERBOUMGALSKI, H ^{[1
]}

LAFYATIS, R ^{[1
]}

CASE, JP ^{[1
]}

FITZGERALD, D ^{[1
]}

WILDER, RL ^{[1
]}

PASTAN, I ^{[1
]}

机构：

[1] NIAMSD,CONNECT TISSUE DIS SECT,BETHESDA,MD 20892

来源：

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1991年 / 13卷 / 2-3期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0192-0561(91)90112-K

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-2-PE40 is a chimeric cytotoxin composed of interleukin 2 (IL-2) fused to a truncated form of Pseudomonas exotoxin (PE) that lacks its binding domain. IL-2-PE40 has been shown to exhibit therapeutic potency in several models in vivo when administered i.p. twice a day. Here we show that the continuous administration of IL-2-PE40 by an osmotic pump specifically prevents the development of adjuvant induced arthritis in rats with an improved therapeutic efficacy as compared to daily repeated i.p. injections. Stabilization of IL-2-PE40 at 37-degrees-C for the continuous administration by pumps was achieved by adding NAD, the substrate for the enzyme portion of the chimeric toxin.

引用

页码：305 / 315

页数：11

共 25 条

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