THE GONADOTROPIN-RELEASING-HORMONE (GNRH) GENE MAPS TO MOUSE CHROMOSOME-14 AND IDENTIFIES A HOMOLOGOUS REGION ON HUMAN CHROMOSOME-8

被引：14

作者：

WILLIAMSON, P ^{[1
]}

LANG, J ^{[1
]}

BOYD, Y ^{[1
]}

机构：

[1] UNIV OXFORD,DEPT HUMAN ANAT,OXFORD OX1 3QX,ENGLAND

来源：

SOMATIC CELL AND MOLECULAR GENETICS | 1991年 / 17卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1007/BF01233626

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The murine gonadotropin-releasing hormone (Gnrh) locus has been mapped to mouse chromosome 14 using a mouse x Chinese hamster somatic cell hybrid panel. The equivalent human locus, known as luteinizing hormone-releasing hormone (LHRH), has been previously mapped to 8p21-8p11.2. Four other loci mapping to the human chromosome 8 short arm have been mapped to mouse chromosome 8; two of these (PLAT, GSR) lie proximal to LHRH, and two (LPL, DEF1) lie distal to LHRH. The localization of Gnrh, the murine homology of LHRH, to mouse chromosome 14 therefore defines a hitherto unrecognized block of homology between man and mouse. Furthermore, it indicates that the region of homology between the human chromosome 8 short arm and mouse chromosome 8 is composed of two separate blocks.

引用

页码：609 / 615

页数：7

共 26 条

[1] ISOLATION OF THE GENE AND HYPOTHALAMIC CDNA FOR THE COMMON PRECURSOR OF GONADOTROPIN-RELEASING-HORMONE AND PROLACTIN RELEASE-INHIBITING FACTOR IN HUMAN AND RAT [J].