MULTIPLE SIMIAN-VIRUS 40 ENHANCER ELEMENTS MEDIATE THE TRANSACTIVATING FUNCTION OF THE X-PROTEIN OF HEPATITIS-B VIRUS

被引：18

作者：

LUBER, B

BURGELT, E

FROMENTAL, C

KANNO, M

KOCH, W

机构：

[1] MAX PLANCK INST BIOCHEM,W-8033 MARTINSRIED,GERMANY

[2] LAB GENET MOLEC EUCARYOTES,F-67085 STRASBOURG,FRANCE

来源：

VIROLOGY | 1991年 / 184卷 / 02期

关键词：

D O I：

10.1016/0042-6822(91)90458-N

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Transient transfections of tissue culture cells with plasmids encoding the X protein of hepatitis B virus result in a transcriptional trans-activation of certain target genes. Our experiments reveal that several individual simian virus 40 enhancer elements and a control element present in the mouse major histocompatibility class I gene H-2Kb are able to mediate the trans-activating function of the X protein. The data suggest that known cellular transcription factors that bind specifically to the multiple enhancer elements participate in trans-activation. © 1991.

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收藏

页码：808 / 813

页数：6

相关论文

共 32 条

[1] CONTROLLED SYNTHESIS OF HBSAG IN A DIFFERENTIATED HUMAN-LIVER CARCINOMA-DERIVED CELL-LINE [J].

ADEN, DP ;

FOGEL, A ;

PLOTKIN, S ;

DAMJANOV, I ;

KNOWLES, BB .

NATURE, 1979, 282 (5739) :615-616

[2] THE HEPATITIS-B VIRUS X-GENE PRODUCT TRANS-ACTIVATES BOTH RNA POLYMERASE-II AND III-PROMOTERS [J].

AUFIERO, B ;

SCHNEIDER, RJ .

EMBO JOURNAL, 1990, 9 (02) :497-504

[3]

CHANG RSM, 1954, P SOC EXP BIOL MED, V87, P440

[4] TRANSCRIPTIONAL ACTIVATION OF HOMOLOGOUS AND HETEROLOGOUS GENES BY THE HEPATITIS-B VIRUS X-GENE PRODUCT IN CELLS PERMISSIVE FOR VIRAL REPLICATION [J].

COLGROVE, R ;

SIMON, G ;

GANEM, D .

JOURNAL OF VIROLOGY, 1989, 63 (09) :4019-4026

[5] THE HELA-CELL PROTEIN TEF-1 BINDS SPECIFICALLY AND COOPERATIVELY TO 2 SV40 ENHANCER MOTIFS OF UNRELATED SEQUENCE [J].

DAVIDSON, I ;

XIAO, JH ;

ROSALES, R ;

STAUB, A ;

CHAMBON, P .

CELL, 1988, 54 (07) :931-942

[6] A SINGLE ELEMENT WITHIN THE HEPATITIS-B VIRUS ENHANCER BINDS MULTIPLE PROTEINS AND RESPONDS TO MULTIPLE STIMULI [J].

FAKTOR, O ;

BUDLOVSKY, S ;

BENLEVY, R ;

SHAUL, Y .

JOURNAL OF VIROLOGY, 1990, 64 (04) :1861-1863

[7]

FAKTOR O, 1990, ONCOGENE, V5, P867

[8] COOPERATIVITY AND HIERARCHICAL LEVELS OF FUNCTIONAL-ORGANIZATION IN THE SV40 ENHANCER [J].

FROMENTAL, C ;

KANNO, M ;

NOMIYAMA, H ;

CHAMBON, P .

CELL, 1988, 54 (07) :943-953

[9] RECOMBINANT GENOMES WHICH EXPRESS CHLORAMPHENICOL ACETYLTRANSFERASE IN MAMMALIAN-CELLS [J].

GORMAN, CM ;

MOFFAT, LF ;

HOWARD, BH .

MOLECULAR AND CELLULAR BIOLOGY, 1982, 2 (09) :1044-1051

[10] NEW TECHNIQUE FOR ASSAY OF INFECTIVITY OF HUMAN ADENOVIRUS 5 DNA [J].

GRAHAM, FL ;

VANDEREB, AJ .

VIROLOGY, 1973, 52 (02) :456-467

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