NUCLEAR-MAGNETIC-RESONANCE AS A MEASURE OF CEREBRAL METABOLISM - EFFECTS OF HYPERTONIC SALINE RESUSCITATION

被引:9
作者
WISNER, DH [1 ]
BATTISTELLA, FD [1 ]
FRESHMAN, SP [1 ]
WEBER, CJ [1 ]
KAUTEN, RJ [1 ]
机构
[1] UNIV CALIF DAVIS,SACRAMENTO MED CTR,MED CTR,DEPT NEUROSURG,SACRAMENTO,CA 95817
关键词
D O I
10.1097/00005373-199203000-00013
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Fears of central nervous system dysfunction from acute hypernatremia and hyperosmolarity with hypertonic saline resuscitation are often cited. We used high-energy phosphate nuclear magnetic resonance to investigate resuscitation effects on cerebral metabolism. Rats were instrumented for hemodynamic monitoring and fluid infusion and a phosphorus surface coil placed on their skulls. After shimming, baseline spectra were obtained. Animals were then bled for one hour to a mean arterial pressure (MAP) of 45 mm Hg, followed by resuscitation for one hour to a MAP of 75 mm Hg with lactated Ringer's (LR, n = 17) or 7.5% hypertonic saline (HS, n = 25). Spectra were obtained again and analyzed for the ratio of high-energy phosphocreatine (PCr) to low-energy inorganic phosphate (P(i)). Intracellular hydrogen ion concentration [H +] was calculated from the PCr/P(i) shift. [GRAPHICS] Conclusions: (1) Hypertonic saline results in a decreased intracellular pH compared with LR without associated changes in high-energy phosphate metabolism. (2) Decreases in pH may be the result of cell dehydration rather than metabolic dysfunction.
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页码:351 / 358
页数:8
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