SYSTEMATIC OPTIMIZATION OF CAPILLARY ELECTROPHORETIC SEPARATION OF SULFONAMIDES

被引：32

作者：

NG, CL ^{[1
]}

LEE, HK ^{[1
]}

LI, SFY ^{[1
]}

机构：

[1] NATL UNIV SINGAPORE,DEPT CHEM,KENT RIDGE,SINGAPORE 0511,SINGAPORE

来源：

JOURNAL OF CHROMATOGRAPHY | 1992年 / 598卷 / 01期

关键词：

D O I：

10.1016/0021-9673(92)85123-B

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The use of an optimization scheme for the separation of a group of sulphonamides is described. This scheme utilizes an interpretive optimization approach to predict the optimum conditions for the separation of a group of eight sulphonamides. By conducting nine preplanned experiments that span the maximum working range of the system, overall optimum conditions for separation can be obtained. To confirm the validity of the optimization procedure, additional experiments using the optimum conditions predicted by the scheme were performed. The results demonstrated that satisfactory separation could be achieved by using the optimum separation conditions predicted by the scheme.

引用

页码：133 / 138

页数：6

共 15 条

[1] MONITORING OF VETERINARY DRUG RESIDUES BY A COMBINATION OF CONTINUOUS-FLOW TECHNIQUES AND COLUMN-SWITCHING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY .1. SULFONAMIDES IN EGG, MEAT AND MILK USING POST-COLUMN DERIVATIZATION WITH DIMETHYLAMINOBENZALDEHYDE [J].

AERTS, MML ;

BEEK, WMJ ;

BRINKMAN, UAT .

JOURNAL OF CHROMATOGRAPHY, 1988, 435 (01) :97-112

[2] SEPARATION OF DANSYLATED METHYLAMINE AND DANSYLATED METHYL-D3-AMINE BY MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY WITH METHANOL-MODIFIED MOBILE PHASE [J].

BUSHEY, MM ;

JORGENSON, JW .

ANALYTICAL CHEMISTRY, 1989, 61 (05) :491-493

[3] NARROW-BORE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY SEPARATIONS OF 22 SULFONAMIDES [J].

CROSS, RF .

JOURNAL OF CHROMATOGRAPHY, 1989, 478 (02) :422-428

[4] OPTIMIZATION OF SOLVENT STRENGTH AND SELECTIVITY FOR REVERSED-PHASE LIQUID-CHROMATOGRAPHY USING AN INTERACTIVE MIXTURE-DESIGN STATISTICAL TECHNIQUE [J].

GLAJCH, JL ;

KIRKLAND, JJ ;

SQUIRE, KM ;

MINOR, JM .

JOURNAL OF CHROMATOGRAPHY, 1980, 199 (OCT) :57-79

[5] EFFECT OF BUFFER PH AND PEPTIDE COMPOSITION ON THE SELECTIVITY OF PEPTIDE SEPARATIONS BY CAPILLARY ZONE ELECTROPHORESIS [J].

GROSSMAN, PD ;

WILSON, KJ ;

PETRIE, G ;

LAUER, HH .

ANALYTICAL BIOCHEMISTRY, 1988, 173 (02) :265-270

[6] ANALYTICAL AND MICROPREPARATIVE ULTRAHIGH RESOLUTION OF OLIGONUCLEOTIDES BY POLYACRYLAMIDE-GEL HIGH-PERFORMANCE CAPILLARY ELECTROPHORESIS [J].

GUTTMAN, A ;

COHEN, AS ;

HEIGER, DN ;

KARGER, BL .

ANALYTICAL CHEMISTRY, 1990, 62 (02) :137-141

[7] METHOD FOR THE ISOLATION AND LIQUID-CHROMATOGRAPHIC DETERMINATION OF 8 SULFONAMIDES IN MILK [J].

LONG, AR ;

SHORT, CR ;

BARKER, SA .

JOURNAL OF CHROMATOGRAPHY, 1990, 502 (01) :87-94

[8] SEPARATION AND DETERMINATION OF ASPOXICILLIN IN HUMAN PLASMA BY MICELLAR ELECTROKINETIC CHROMATOGRAPHY WITH DIRECT SAMPLE INJECTION [J].

NISHI, H ;

FUKUYAMA, T ;

MATSUO, M .

JOURNAL OF CHROMATOGRAPHY, 1990, 515 :245-255

[9]

Nishi H., 1989, J MICROCOLUMN, P234, DOI DOI 10.1002/MCS.1220010506

[10] SEPARATION OF WATER-SOLUBLE AND FAT-SOLUBLE VITAMINS BY MICELLAR ELECTROKINETIC CHROMATOGRAPHY [J].

ONG, CP ;

NG, CL ;

LEE, HK ;

LI, FY .

JOURNAL OF CHROMATOGRAPHY, 1991, 547 (1-2) :419-428

← 1 2 →