RESPONSE OF CENTRAL PAIN SYNDROMES TO INTRAVENOUS LIDOCAINE

被引：33

作者：

BACKONJA, M

GOMBAR, KA

机构：

[1] Pain Clinic, University of Wisconsin Hospital and Clinics, Madison, Wisconsin

[2] Department of Neurology, University of Wisconsin Hospital and Clinics, Madison, Wisconsin

[3] W.S. Middleton Veterans Administration Hospital, Madison, Wisconsin

来源：

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT | 1992年 / 7卷 / 03期

关键词：

CENTRAL NEUROPATHIC PAIN; LIDOCAINE; PLACEBO; MECHANISMS;

D O I：

10.1016/S0885-3924(06)80010-2

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

In this study, 8 patients with central pain syndromes, 6 with hemispheric lesions, and 2 with spinal cord lesions were treated with a 1 mg/kg dose of intravenous lidocaine. Patients first received the same volume of normal saline, in single-blind fashion, to monitor placebo effects. Of the 8 patients, 7 responded to lidocaine, and only 1 responded to normal saline. Responses ranged from partial to complete. All components of central pain, including constant pain, paroxysms of pain, and evoked pain, responded to lidocaine. In addition, 3 patients had pain relief that lasted for 8-20 wk. These findings, which are in agreement with two previous open-label studies, suggest that a single dose of a local anesthetic, lidocaine, can provide lasting pain relief for patients with central pain syndromes. This analgesic action may be central, and possibly supraspinal, at least in patients with hemispheric lesions.

引用

页码：172 / 178

页数：7

共 18 条

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