INVITRO INTERACTION OF FENRETINIDE WITH PLASMA RETINOL-BINDING PROTEIN AND ITS FUNCTIONAL CONSEQUENCES

被引:93
作者
BERNI, R [1 ]
FORMELLI, F [1 ]
机构
[1] IST NAZL STUDIO & CURA TUMORI,I-20133 MILAN,ITALY
关键词
RETINOL-BINDING PROTEIN; FENRETINIDE; N-ETHYLRETINAMIDE; RETINOID BINDING; TRANSTHYRETIN; PLASMA RETINOL LEVEL;
D O I
10.1016/0014-5793(92)81046-O
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The synthetic retinoid fenretinide (4-HPR; N-[4-hydroxyphenyl] all-trans-retinamide) interacts with plasma apo-retinol-binding protein (RBP) to form a tight complex (K'd almost-equal-to 0.2-mu-M) which does not exhibit binding affinity to transthyretin (TTR). Therefore, a substantial modification of the retinol hydroxyl group does not appear to affect the interaction with RBP but does drastically interfere with the protein-protein recognition. The remarkable early reduction in plasma retinol level induced by fenretinide administration may be associated with the high binding affinity of this retinoid to RBP and to its interference with the RBP TTR complex formation.
引用
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页码:43 / 45
页数:3
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