IMMUNODEFICIENCY DUE TO A FAULTY INTERACTION BETWEEN T-CELLS AND B-CELLS

被引：15

作者：

LAMAN, JD ^{[1
]}

CLAASSEN, E ^{[1
]}

NOELLE, RJ ^{[1
]}

机构：

[1] DARTMOUTH COLL SCH MED,DEPT MICROBIOL,LEBANON,NH 03756

来源：

CURRENT OPINION IN IMMUNOLOGY | 1994年 / 6卷 / 04期

关键词：

D O I：

10.1016/0952-7915(94)90153-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The identification of the ligand for CD40, gp39, which is expressed on the membrane of activated CD4(+) T-helper cells, has sparked intense investigation into the roles of this molecule in physiological B-cell activation. Recently, it has become clear that some human immunodeficiencies, such as X-linked hyper IgM syndrome and common variable immunodeficiency are linked to mutations in the gp39 gene or are a result of defective expression of gp39, leading to suboptimal, or a lack of, B-cell activation by T-helper cells.

引用

页码：636 / 641

页数：6

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