DEVELOPMENT OF LATERAL-LINE ORGANS IN THE AXOLOTL

Lateral line sensory receptors and their cranial nerves in axolotls arise from a dorsolateral series of placodes, including the octaval placode, that gives rise to the inner ear and the octaval nerve. Anterodorsal and anteroventral placodes occur rostral to the octaval placode and give rise to anterodorsal and anteroventral lateral line nerves and electroreceptors and mechanoreceptors of the snout, cheek, and lower jaw. Middle, supratemporal, and posterior placodes occur caudal to the octaval placode and give rise to similarly named lateral line nerves, electroreceptors and mechanoreceptors of the occipital region of the head, and trunk neuromasts. All placodes, except the posterior placode, elongate, forming sensory ridges, following the genesis of sensory ganglia. Primary mechanoreceptor primordia begin to form within the central zone of the sensory ridges at stage 36; primary electroreceptor primordia originate within the lateral zones of these ridges at stage 38. The first primary mechanoreceptors erupt during stage 37; all primary mechanoreceptors have erupted at hatching (stage 41). Primary electroreceptors begin to erupt at stage 43. Secondary mechanoreceptor primordia begin to form in 1-week-old larvae and erupt 1-2 weeks later. Secondary electroreceptor primordia also begin to form in 1-week-old larvae and continue until clusters of two to five electoreceptors are formed. The developmental stages thought to characterize lateral line placodes in the earliest gnathostomes suggest that this ancestral ontogeny has been truncated in modern amphibians, and ontogenetic mechanisms underlying placodal differentiation are suggested. (C) 1994 Wiley-Liss, Inc.