BETA-ADRENERGIC BLOCKING-AGENTS AND THE TREATMENT OF GLAUCOMA

被引:75
作者
ZIMMERMAN, TJ [1 ]
BOGER, WP [1 ]
机构
[1] HARVARD UNIV, SCH MED, DEPT OPHTHALMOL, BOSTON, MA 02115 USA
关键词
agonist; alpha adrenergic receptors; antagonist; aqueous humor dynamics; beta adrenergic receptors; beta-adrenergic blocking agents; epinephrine; glaucoma; intraocular pressure; ocular hypotensive agents; outflow facility; pilocarpine; timolol;
D O I
10.1016/0039-6257(79)90228-5
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
The autonomic nervous system is divided into the parasympathetic and sympathetic systems, with three types of adrenergic receptors: alpha (smooth muscle contraction), beta1 (cardiac acceleration and fatty acid mobilization) and beta2 (smooth muscle relaxation). Substances affecting the function of the adrenergic system are the agonists or stimulators, which mimic the effects of endogenous norepinephrine or epinephrine, and antagonists or blockers, which block the receptors and prevent stimulation by the agonists. Autonomic stimulation in the eye mediates various changes which apparently affect outflow facility and rate of formation of aqueous humor. Alteration of either or both of these factors by autonomic agonists or antagonists may have a direct or an indirect effect on intraocular pressure. Beta-adrenergic blocking substances have been used to treat a variety of diseases. Some of the effects of these drugs are attributable to properties other than beta blockade, such as intrinsic sympathomimetic activity and local anaesthetic activity. Side effects of this class of drugs require caution in cases of congestive heart failure and in asthmatics. Autonomic agents used in the treatment of ocular hypertension and glaucoma include pilocarpine, a cholinergic agonist, epinephrine, an adrenergic agonist, and various beta adrenergic blockers or antagonists including propranolol, atenolol and timolol. The physico-chemical properties and pharmacokinetics of timolol are reviewed. Data showing a significant reduction in intraocular pressure as a result of ocular instillation of timolol are presented. Reduction of the rate of aqueous formation appears to be the mechanism of action. A low incidence of non-serious side effects is reported. © 1979.
引用
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页码:347 / 362
页数:16
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