ELECTRON-MICROSCOPY OF HEPATITIS-B VIRUS COMPONENTS IN CHRONIC ACTIVE LIVER-DISEASE

被引:9
作者
DEVOS, R
RAY, MB
DESMET, VJ
机构
关键词
D O I
10.1136/jcp.32.6.590
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Eighteen liver biopsy specimens from patients with hepatitis B surface antigen (HBsAg) positive chronic aggressive hepatitis were studied by electron microscopy. All cases were selected on the basis of positive liver cell membrane fluorescence for HBsAg on immunohistochemical investigation. Striking changes in the morphology of the liver cell membrane were observed in nearly all cases. Furthermore, a dual aspect of hepatitis B core antigen (HBcAg) is described. HBcAg particles may occur as either 'naked' or 'cloudy' particles surrounded by semi electron dense material. The nature of the 'cloud' remains to be identified.
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页码:590 / 600
页数:11
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