DOES ADRENAL GRAFT ENHANCE RECOVERY OF DOPAMINERGIC-NEURONS IN PARKINSONS-DISEASE

被引:109
作者
HIRSCH, EC [1 ]
DUYCKAERTS, C [1 ]
JAVOYAGID, F [1 ]
HAUW, JJ [1 ]
AGID, Y [1 ]
机构
[1] HOP LA PITIE SALPETRIERE,LAB NEUROPATHOL R ESCOUROLLE,F-75651 PARIS 13,FRANCE
关键词
D O I
10.1002/ana.410270615
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
A 54‐year‐old man with a 5‐year history of Parkinson's disease was treated with an autograft of adrenal medulla into the right caudate nucleus and died 4 months after surgery. Postmortem examination revealed that the graft was necrotic. It consisted mainly of reticulin and collagen fibrosis without catecholaminergic cell bodies identified either by immunohistochemistry or by situ hybridization with labeled human tyrosine hydroxylase (TH) cDNA probe. Sparse TH‐immunoreactive fibers, which did not stain for dopamine‐beta‐hydroxylase (DBH), ran through the graft. In contrast, intense staining for these catecholaminergic markers was found in the untransplanted adrenal medulla. Densely packed TH‐positive, DHB‐negative fibers were found in a restricted zone of the host striatum at the periphery of the graft. This effect was selective since the density of other neurons was not modified. The present study describes an additional patient in whom adrenal medulla autotransplantation failed to improve the parkinsonian disability. It suggests, however, that adrenal medulla grafts may stimulate the sprouting of striatal dopaminergic fibers in a limited zone of the grafted striatum. Copyright © 1990 American Neurological Association
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页码:676 / 682
页数:7
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